Nutrient sensing and metabolic decisions

被引：116

作者：

Lindsley, JE ^{[1
]}

Rutter, J ^{[1
]}

机构：

[1] Univ Utah, Sch Med, Dept Biochem, Salt Lake City, UT 84132 USA

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY | 2004年 / 139卷 / 04期

关键词：

AMPK; AMP kinase; hexosamine; O-GlcNAC; mTOR; PASK; PAS kinase; Sir2;

D O I：

10.1016/j.cbpc.2004.06.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cells have several sensory systems that detect energy and metabolic status and adjust flux through metabolic pathways accordingly. Many of these sensors and signaling pathways are conserved frorn yeast to mammals. In this review, we bring together information about five different nutrient-sensing pathways (AMP kinase, rnTOR, PAS kinase, hexosamine biosynthesis and Sir2), highlighting their similarities, differences and roles in disease. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：543 / 559

页数：17

共 50 条

[1] Nutrient sensing and inflammation in metabolic diseases
Gökhan S. Hotamisligil
Ebru Erbay
Nature Reviews Immunology, 2008, 8 : 923 - 934
[2] Nutrient sensing and inflammation in metabolic diseases
Hotamisligil, Goekhan S.
Erbay, Ebru
NATURE REVIEWS IMMUNOLOGY, 2008, 8 (12) : 923 - 934
[3] Impact of lysosomal nutrient sensing on metabolic dysregulation
Bhardwaj, M.
FEBS OPEN BIO, 2024, 14 : 26 - 26
[4] The metabolic impact of small intestinal nutrient sensing
Frank A. Duca
T. M. Zaved Waise
Willem T. Peppler
Tony K. T. Lam
Nature Communications, 12
[5] The metabolic impact of small intestinal nutrient sensing
Duca, Frank A.
Waise, T. M. Zaved
Peppler, Willem T.
Lam, Tony K. T.
NATURE COMMUNICATIONS, 2021, 12 (01)
[6] Nutrient and Metabolic Sensing in T Cell Responses
Wei, Jun
Raynor, Jana
Nguyen, Thanh-Long M.
Chi, Hongbo
FRONTIERS IN IMMUNOLOGY, 2017, 8
[7] Nutrient sensing and utilization: Getting to the heart of metabolic flexibility
Griffin, Timothy M.
Humphries, Kenneth M.
Kinter, Michael
Lim, Hui-Ying
Szweda, Luke I.
BIOCHIMIE, 2016, 124 : 74 - 83
[8] Nutrient sensing and metabolic stress pathways in innate immunity
Tsalikis, Jessica
Croitoru, David O.
Philpott, Dana J.
Girardin, Stephen E.
CELLULAR MICROBIOLOGY, 2013, 15 (10) : 1632 - 1641
[9] Modeling metabolic homeostasis and nutrient sensing in Drosophila: implications for aging and metabolic diseases
Owusu-Ansah, Edward
Perrimon, Norbert
DISEASE MODELS & MECHANISMS, 2014, 7 (03) : 343 - 350
[10] The SLC transporter in nutrient and metabolic sensing, regulation, and drug development
Zhang, Yong
Zhang, Yuping
Sun, Kun
Meng, Ziyi
Chen, Ligong
JOURNAL OF MOLECULAR CELL BIOLOGY, 2019, 11 (01) : 1 - 13

← 1 2 3 4 5 →