Epstein-Barr Virus-associated Intracranial Leiomyosarcoma in an HIV-positive Adolescent

被引:24
作者
Gupta, Sweta [1 ]
Havens, Peter L. [2 ]
Southern, James F. [3 ]
Firat, Selim Y. [4 ]
Jogal, Sachin S. [1 ]
机构
[1] Childrens Hosp Wisconsin, Dept Pediat Hematol Oncol, Med Coll Wisconsin, Milwaukee, WI 53226 USA
[2] Childrens Hosp Wisconsin, Dept Infect Dis, Med Coll Wisconsin, Milwaukee, WI 53226 USA
[3] Childrens Hosp Wisconsin, Dept Pathol, Med Coll Wisconsin, Milwaukee, WI 53226 USA
[4] Med Coll Wisconsin, Dept Radiat Oncol, Milwaukee, WI 53226 USA
关键词
brain; leiomyosarcoma; human immunodeficiency virus; Epstein-Barr virus; HUMAN-IMMUNODEFICIENCY-VIRUS; SOFT-TISSUE SARCOMAS; SMOOTH-MUSCLE TUMORS; PHASE-II TRIAL; T-CELLS; AIDS; TRANSPLANTATION; GEMCITABINE; DOCETAXEL; INFECTION;
D O I
10.1097/MPH.0b013e3181c80bf3
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
A 17-year-old African American female with human immunodeficiency virus infection presented with an unresectable intracranial neoplasm with mass effect upon the brainstem. Stereotactic biopsy revealed an Epstein-Barr virus (EBV)-associated leiomyosarcoma. Radiation therapy and gemcitabine were used to shrink the mass with the aim to make it surgically resectable. Prolonged neutropenia and recurrent skin infections led to the discontinuation of gemcitabine. The mass stabilized after radiation therapy and has decreased in size in 15 months of follow-up. EBV has been demonstrated in most smooth muscle tumors associated with acquired immunodeficiency syndrome and other immunocompromised states. This is the first documented case of an EBV-positive intracranial leiomyosarcoma in a pediatric human immunodeficiency virus patient.
引用
收藏
页码:E144 / E147
页数:4
相关论文
共 27 条
[1]  
Anderson Pete, 2008, Cancer Control, V15, P38
[2]  
Appleby P, 2000, JNCI-J NATL CANCER I, V92, P1823, DOI 10.1093/jnci/92.22.1823
[3]   Docetaxel and gemcitabine combination in 133 advanced soft-tissue sarcomas: A retrospective analysis [J].
Bay, Jacques-Olivier ;
Ray-Coquard, Isabelle ;
Fayette, Jerome ;
Leyvraz, Serge ;
Cherix, Stephane ;
Piperno-Neumann, Sophie ;
Chevreau, Christine ;
Isambert, Nicolas ;
Brain, Etienne ;
Emile, Georges ;
Le Cesne, Axel ;
Cioffi, Angela ;
Kwiatkowski, Fabrice ;
Coindre, Jean-Michel ;
Bui, Nguyon Binh ;
Peyrade, Frederic ;
Blay, Jean-Yves .
INTERNATIONAL JOURNAL OF CANCER, 2006, 119 (03) :706-711
[4]   EPSTEIN-BARR VIRUS-INDUCED CELL-FUSION [J].
BAYLISS, GJ ;
WOLF, H .
NATURE, 1980, 287 (5778) :164-165
[5]   Primary dural leiomyosarcoma in a patient infected with human immunodeficiency virus: Case report [J].
Bejjani, GK ;
Stopak, B ;
Schwartz, A ;
Santi, R .
NEUROSURGERY, 1999, 44 (01) :199-202
[6]   Risk of cancer in children with AIDS [J].
Biggar, RJ ;
Frisch, M ;
Goedert, JJ .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2000, 284 (02) :205-209
[7]   Primary intracranial neoplasms in patients with HIV [J].
Blumenthal, DT ;
Raizer, JJ ;
Rosenblum, MK ;
Bilsky, MH ;
Hariharan, S ;
Abrey, LE .
NEUROLOGY, 1999, 52 (08) :1648-1651
[8]   Intracranial leiomyosarcoma in a patient with AIDS [J].
Brown, HG ;
Burger, PC ;
Olivi, A ;
Sills, AK ;
Barditch-Crovo, PA ;
Lee, RR .
NEURORADIOLOGY, 1999, 41 (01) :35-39
[9]   Treatment of Epstein-Barr virus-associated malignancies with specific T cells [J].
Gottschalk, S ;
Heslop, HE ;
Rooney, CM .
ADVANCES IN CANCER RESEARCH, VOL 84, 2002, 84 :175-201
[10]   Gemcitabine and docetaxel in patients with unresectable leiomyosarcoma: Results of a phase II trial [J].
Hensley, ML ;
Maki, R ;
Venkatraman, E ;
Geller, G ;
Lovegren, M ;
Aghajanian, C ;
Sabbatini, P ;
Tong, W ;
Barakat, R ;
Spriggs, DR .
JOURNAL OF CLINICAL ONCOLOGY, 2002, 20 (12) :2824-2831