Potential of Mesenchymal Stem Cells in the Rejuvenation of the Aging Immune System

被引：20

作者：

Yeo, Genieve Ee Chia ^{[1
]}

Ng, Min Hwei ^{[1
]}

Nordin, Fazlina Binti ^{[1
]}

Law, Jia Xian ^{[1
]}

机构：

[1] Univ Kebangsaan Malaysia Med Ctr, Ctr Tissue Engn & Regenerat Med, Fac Med, Jalan Yaacob Latif, Cheras 56000, Malaysia

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 11期

关键词：

mesenchymal stem cells; aging; inflammaging; frailty; immune system; REGULATORY T-CELLS; STROMAL CELLS; B-CELLS; LYMPHOCYTE-PROLIFERATION; CYTOKINE PRODUCTION; INFLUENZA VACCINE; OXIDATIVE-STRESS; ELDERLY-PATIENTS; DENDRITIC CELLS; OLDER-ADULTS;

D O I：

10.3390/ijms22115749

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rapid growth of the geriatric population has been made possible with advancements in pharmaceutical and health sciences. Hence, age-associated diseases are becoming more common. Aging encompasses deterioration of the immune system, known as immunosenescence. Dysregulation of the immune cell production, differentiation, and functioning lead to a chronic subclinical inflammatory state termed inflammaging. The hallmarks of the aging immune system are decreased naive cells, increased memory cells, and increased serum levels of pro-inflammatory cytokines. Mesenchymal stem cell (MSC) transplantation is a promising solution to halt immunosenescence as the cells have excellent immunomodulatory functions and low immunogenicity. This review compiles the present knowledge of the causes and changes of the aging immune system and the potential of MSC transplantation as a regenerative therapy for immunosenescence.

引用

页数：31

共 215 条

[1] Long-Term Engraftment of Primary Bone Marrow Stromal Cells Repairs Niche Damage and Improves Hematopoietic Stem Cell Transplantation [J].

Abbuehl, Jean-Paul ;

Tatarova, Zuzana ;

Held, Werner ;

Huelsken, Joerg .

CELL STEM CELL, 2017, 21 (02) :241-+

[2] Inflammatory cytokines and immune system modulation by aerobic versus resisted exercise training for elderly [J].

Abd El-Kader, Shehab M. ;

Al-Shreef, Fadwa M. .

AFRICAN HEALTH SCIENCES, 2018, 18 (01) :120-131

[3] Immunomodulatory properties of umbilical cord vein mesenchymal stromal cells influenced by gestational age and in vitro expansion [J].

Abolhasani, Massume ;

Rezaee, Mohammad Ali ;

Mohammadi, Mehdi ;

Ghadimi, Tayyeb ;

Mohammadi, Mobin ;

Rahmani, Mohammad Reza .

IMMUNOLOGY LETTERS, 2018, 194 :62-68

[4] Advanced age in horses affects divisional history of T cells and inflammatory cytokine production [J].

Adams, A. A. ;

Breathnach, C. C. ;

Katepalli, M. P. ;

Kohler, K. ;

Horohov, D. W. .

MECHANISMS OF AGEING AND DEVELOPMENT, 2008, 129 (11) :656-664

[5] Human mesenchymal stem cells modulate allogeneic immune cell responses [J].

Aggarwal, S ;

Pittenger, MF .

BLOOD, 2005, 105 (04) :1815-1822

[6] Increased Reactivity of Dendritic Cells from Aged Subjects to Self-Antigen, the Human DNA [J].

Agrawal, Anshu ;

Tay, Aa ;

Ton, Steven ;

Agrawal, Sudhanshu ;

Gupta, Sudhir .

JOURNAL OF IMMUNOLOGY, 2009, 182 (02) :1138-1145

[7] HMGB2 orchestrates the chromatin landscape of senescence-associated secretory phenotype gene loci [J].

Aird, Katherine M. ;

Iwasaki, Osamu ;

Kossenkov, Andrew V. ;

Tanizawa, Hideki ;

Fatkhutdinov, Nail ;

Bitler, Benjamin G. ;

Le, Linh ;

Alicea, Gretchen ;

Yang, Ting-Lin ;

Johnson, Brad ;

Noma, Ken-ichi ;

Zhang, Rugang .

JOURNAL OF CELL BIOLOGY, 2016, 215 (03) :325-334

[8] Reduced-intensity conditioning is a reasonable alternative for Philadelphia chromosome-positive acute lymphoblastic leukemia among elderly patients who have achieved negative minimal residual disease: a report from the Adult Acute Lymphoblastic Leukemia Working Group of the JS']JSHCT [J].

Akahoshi, Yu ;

Nishiwaki, Satoshi ;

Arai, Yasuyuki ;

Harada, Kaito ;

Najima, Yuho ;

Kanda, Yoshinobu ;

Shono, Katsuhiro ;

Ota, Shuichi ;

Fukuda, Takahiro ;

Uchida, Naoyuki ;

Shiratori, Souichi ;

Tanaka, Masatsugu ;

Tanaka, Junji ;

Atsuta, Yoshiko ;

Kako, Shinichi .

BONE MARROW TRANSPLANTATION, 2020, 55 (07) :1317-1325

[9] Long-term cytomegalovirus infection leads to significant changes in the composition of the CD8+ T-cell repertoire, which may be the basis for an imbalance in the cytokine production profile in elderly persons [J].

Almanzar, G ;

Schwaiger, S ;

Jenewein, B ;

Keller, M ;

Herndler-Brandstetter, D ;

Würzner, R ;

Schönitzer, D ;

Grubeck-Loebenstein, B .

JOURNAL OF VIROLOGY, 2005, 79 (06) :3675-3683

[10] Age-related changes in natural killer cell receptors from childhood through old age [J].

Almeida-Oliveira, Aline ;

Smith-Carvalho, Monique ;

Porto, Luis Cristovao ;

Cardoso-Oliveira, Juliana ;

Ribeiro, Aline dos Santos ;

Falcao, Rosangela Rosa ;

Abdelhay, Eliana ;

Bouzas, Luis Fernando ;

Santos Thuler, Luiz Claudio ;

Ornellas, Maria Helena ;

Diamond, Hilda Rachel .

HUMAN IMMUNOLOGY, 2011, 72 (04) :319-329

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