The Timing of Melatonin Administration Is Crucial for Its Antidepressant-Like Effect in Mice

被引:24
作者
Estrada-Reyes, Rosa [1 ]
Valdes-Tovar, Marcela [2 ]
Arrieta-Baez, Daniel [3 ]
Maria Dorantes-Barron, Ana [1 ]
Quero-Chavez, Daniel [2 ]
Solis-Chagoyan, Hector [2 ]
Argueta, Jesus [2 ]
Dubocovich, Margarita L. [4 ]
Benitez-King, Gloria [2 ]
机构
[1] Inst Nacl Psiquiatria Ramon de la Fuente Muniz, Direcc Invest Neurociencias, Lab Fitofarmacol, Calzada Mexico Xochimilco 101, Ciudad De Mexico 14370, Mexico
[2] Inst Nacl Psiquiatria Ramon de la Fuente Muniz, Subdirecc Invest Clin, Lab Neurofarmacol, Calzada Mexico Xochimilco 101, Ciudad De Mexico 14370, Mexico
[3] Inst Politecn Nacl, CNMN Luis Enrique Erro S-N Unidad Profes Adolfo L, Ciudad De Mexico 07738, Mexico
[4] Univ Buffalo SUNY, Jacobs Sch Med & Biomed Sci, Dept Pharmacol & Toxicol, 955 Main St, Buffalo, NY 14203 USA
关键词
melatonin; zeitgeber time; antidepressant-like effect; behavioral despair; forced-swimming test; tail suspension test; TAIL SUSPENSION TEST; PINEAL-GLAND; RAT-BRAIN; SYNAPTIC-TRANSMISSION; CEREBROSPINAL-FLUID; BEHAVIORAL DESPAIR; PLASMA MELATONIN; OXIDATIVE STRESS; GENE-EXPRESSION; C3H/HEN MICE;
D O I
10.3390/ijms19082278
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Melatonin is synthesized by the pineal gland with a circadian rhythm in synchrony with the environmental light/dark cycle. A gradual increase in circulating levels of melatonin occur after lights off, reaching its maximum around the middle of the dark phase. Agonists of melatonin receptors have proved effectiveness as antidepressants in clinical trials. However, there is contradictory evidence about the potential antidepressant effect of melatonin itself. Herein we studied melatonin administration in mice at two zeitgeber times (ZT; ZT = 0 lights on; 12:12 L/D), one hour before the beginning (ZT11) and at the middle (ZT18) of the dark phase after either a single or a three-dose protocol. Behavioral despair was assessed through a forced-swimming test (FST) or a tail suspension test (TST), at ZT18.5. A single dose of 4 mg/kg melatonin at ZT11 was effective to reduce the immobility time in both tests. However, acute administration of melatonin at ZT18 was not effective in mice subjected to FST, and a higher dose (16 mg/kg) was required to reduce immobility time in the TST. A three-dose administration protocol of 16 mg/kg melatonin (ZT18, ZT11, and ZT18) significantly reduced immobility time in FST. Data indicate that the timely administration of melatonin could improve its antidepressant-like effect.
引用
收藏
页数:15
相关论文
共 60 条
  • [41] DEPRESSION - NEW ANIMAL-MODEL SENSITIVE TO ANTIDEPRESSANT TREATMENTS
    PORSOLT, RD
    LEPICHON, M
    JALFRE, M
    [J]. NATURE, 1977, 266 (5604) : 730 - 732
  • [42] Anti-depressant action of melatonin in chronic forced swimming-induced behavioral despair in mice, role of peripheral benzodiazepine receptor modulation
    Raghavendra, V
    Kaur, G
    Kulkarni, SK
    [J]. EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2000, 10 (06) : 473 - 481
  • [43] Melatonin synergizes with citalopram to induce antidepressant- like behavior and to promote hippocampal neurogenesis in adult mice
    Ramirez-Rodriguez, Gerardo
    Maritza Vega-Rivera, Nelly
    Oikawa-Sala, Julian
    Gomez-Sanchez, Ariadna
    Ortiz-Lopez, Leonardo
    Estrada-Camarena, Erika
    [J]. JOURNAL OF PINEAL RESEARCH, 2014, 56 (04) : 450 - 461
  • [44] Melatonin Modulates Cell Survival of New Neurons in the Hippocampus of Adult Mice
    Ramirez-Rodriguez, Gerardo
    Klempin, Friederike
    Babu, Harish
    Benitez-King, Gloria
    Kempermann, Gerd
    [J]. NEUROPSYCHOPHARMACOLOGY, 2009, 34 (09) : 2180 - 2191
  • [45] THE MELATONIN RHYTHM - BOTH A CLOCK AND A CALENDAR
    REITER, RJ
    [J]. EXPERIENTIA, 1993, 49 (08): : 654 - 664
  • [46] Reiter RJ, 2010, CURR NEUROPHARMACOL, V8, P194, DOI 10.2174/157015910792246236
  • [47] Cortico-hippocampal systems involved in memory and cognition: the PMAT framework
    Ritchey, Maureen
    Libby, Laura A.
    Ranganath, Charan
    [J]. CONNECTED HIPPOCAMPUS, 2015, 219 : 45 - 64
  • [48] Orally administered melatonin reduces oxidative stress and proinflammatory cytokines induced by amyloid-β peptide in rat brain:: a comparative, in vivo study versus vitamin C and E
    Rosales-Corral, S
    Tan, DX
    Reiter, RJ
    Valdivia-Velázquez, M
    Martínez-Barboza, G
    Acosta-Martínez, JP
    Ortiz, GG
    [J]. JOURNAL OF PINEAL RESEARCH, 2003, 35 (02) : 80 - 84
  • [49] Circadian Levels of Serotonin in Plasma and Brain after Oral Administration of Tryptophan in Rats
    Sanchez Mateos, Soledad
    Sanchez, Cristina L.
    Paredes, Sergio D.
    Barriga, Carmen
    Rodriguez, Ana B.
    [J]. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2009, 104 (01) : 52 - 59
  • [50] THE TAIL SUSPENSION TEST - A NEW METHOD FOR SCREENING ANTIDEPRESSANTS IN MICE
    STERU, L
    CHERMAT, R
    THIERRY, B
    SIMON, P
    [J]. PSYCHOPHARMACOLOGY, 1985, 85 (03) : 367 - 370