The Timing of Melatonin Administration Is Crucial for Its Antidepressant-Like Effect in Mice

被引:24
作者
Estrada-Reyes, Rosa [1 ]
Valdes-Tovar, Marcela [2 ]
Arrieta-Baez, Daniel [3 ]
Maria Dorantes-Barron, Ana [1 ]
Quero-Chavez, Daniel [2 ]
Solis-Chagoyan, Hector [2 ]
Argueta, Jesus [2 ]
Dubocovich, Margarita L. [4 ]
Benitez-King, Gloria [2 ]
机构
[1] Inst Nacl Psiquiatria Ramon de la Fuente Muniz, Direcc Invest Neurociencias, Lab Fitofarmacol, Calzada Mexico Xochimilco 101, Ciudad De Mexico 14370, Mexico
[2] Inst Nacl Psiquiatria Ramon de la Fuente Muniz, Subdirecc Invest Clin, Lab Neurofarmacol, Calzada Mexico Xochimilco 101, Ciudad De Mexico 14370, Mexico
[3] Inst Politecn Nacl, CNMN Luis Enrique Erro S-N Unidad Profes Adolfo L, Ciudad De Mexico 07738, Mexico
[4] Univ Buffalo SUNY, Jacobs Sch Med & Biomed Sci, Dept Pharmacol & Toxicol, 955 Main St, Buffalo, NY 14203 USA
关键词
melatonin; zeitgeber time; antidepressant-like effect; behavioral despair; forced-swimming test; tail suspension test; TAIL SUSPENSION TEST; PINEAL-GLAND; RAT-BRAIN; SYNAPTIC-TRANSMISSION; CEREBROSPINAL-FLUID; BEHAVIORAL DESPAIR; PLASMA MELATONIN; OXIDATIVE STRESS; GENE-EXPRESSION; C3H/HEN MICE;
D O I
10.3390/ijms19082278
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Melatonin is synthesized by the pineal gland with a circadian rhythm in synchrony with the environmental light/dark cycle. A gradual increase in circulating levels of melatonin occur after lights off, reaching its maximum around the middle of the dark phase. Agonists of melatonin receptors have proved effectiveness as antidepressants in clinical trials. However, there is contradictory evidence about the potential antidepressant effect of melatonin itself. Herein we studied melatonin administration in mice at two zeitgeber times (ZT; ZT = 0 lights on; 12:12 L/D), one hour before the beginning (ZT11) and at the middle (ZT18) of the dark phase after either a single or a three-dose protocol. Behavioral despair was assessed through a forced-swimming test (FST) or a tail suspension test (TST), at ZT18.5. A single dose of 4 mg/kg melatonin at ZT11 was effective to reduce the immobility time in both tests. However, acute administration of melatonin at ZT18 was not effective in mice subjected to FST, and a higher dose (16 mg/kg) was required to reduce immobility time in the TST. A three-dose administration protocol of 16 mg/kg melatonin (ZT18, ZT11, and ZT18) significantly reduced immobility time in FST. Data indicate that the timely administration of melatonin could improve its antidepressant-like effect.
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页数:15
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