Planning feasibility of extremely hypofractionated prostate radiotherapy on a 1.5 T magnetic resonance imaging guided linear accelerator

被引：13

作者：

den Hartogh, Mariska D. ^{[1
]}

de Boer, Hans C. J. ^{[1
]}

De Groot-van Breugel, Eline N. ^{[1
]}

van Zyp, Jochem R. N. van der Voort ^{[1
]}

Hes, Jochem ^{[1
]}

van der Heide, Uulke A. ^{[2
]}

Pos, Floris ^{[2
]}

Haustermans, Karin ^{[3
]}

Depuydt, Tom ^{[3
]}

Smeenk, Robert Jan ^{[4
]}

Kunze-Busch, Martina ^{[4
]}

Raaymakers, Bas W. ^{[1
]}

Kerkmeijer, Linda G. W. ^{[1
,4
]}

机构：

[1] Univ Med Ctr Utrecht, Dept Radiat Oncol, Utrecht, Netherlands

[2] Netherlands Canc Inst, Dept Radiat Oncol, Amsterdam, Netherlands

[3] Univ Hosp Leuven, Dept Radiat Oncol, Leuven, Belgium

[4] Radboud Univ Nijmegen Med Ctr, Dept Radiat Oncol, Nijmegen, Netherlands

来源：

PHYSICS & IMAGING IN RADIATION ONCOLOGY | 2019年 / 11卷

关键词：

MRI-linac; Prostate cancer; Stereotactic body radiotherapy; Hypofractionation; Focal boost; RADIATION-THERAPY; MR-LINAC; IMPACT; FIELD; CANCER; CT; PRECISION; TOXICITY; QUALITY;

D O I：

10.1016/j.phro.2019.07.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background and purpose: Recently, intermediate and high-risk prostate cancer patients have been treated in a multicenter phase II trial with extremely hypofractionated prostate radiotherapy (hypo-FLAME trial). The purpose of the current study was to investigate whether a 1.5 T magnetic resonance imaging guided linear accelerator (MRI-linac) could achieve complex dose distributions of a quality similar to conventional linac state-of-the-art prostate treatments. Materials and methods: The clinically delivered treatment plans of 20 hypo-FLAME patients (volumetric modulated arc therapy, 10 MV, 5 mm leaf width) were included. Prescribed dose to the prostate was 5 x 7 Gy, with a focal tumor boost up to 5 x 10 Gy. MRI-linac treatment plans (intensity modulated radiotherapy, 7 MV, 7 mm leaf width, fixed collimator angle and 1.5 T magnetic field) were calculated. Dose distributions were compared. Results: In both conventional and MRI-linac treatment plans, the V35Gy to the whole prostate was > 99% in all patients. Mean dose to the gross tumor volume was 45 Gy for conventional and 44 Gy for MRI-linac plans, respectively. Organ at risk doses were met in the majority of plans, except for a rectal V35Gy constraint, which was exceeded in one patient, by 1 cc, for both modalities. The bladder V32Gy and V28Gy constraints were exceeded in two and one patient respectively, for both modalities. Conclusion: Planning of stereotactic radiotherapy with focal ablative boosting in prostate cancer on a high field MRI-linac is feasible with the current MRI-linac properties, without deterioration of plan quality compared to conventional treatments.

引用

页码：16 / 20

页数：5

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