An Efficient Chemical Synthesis of Scutellarein: An in Vivo Metabolite of Scutellarin

被引：13

作者：

Dong, Ze-Xi ^{[1
]}

Li, Nian-Guang ^{[1
]}

Zhang, Peng-Xuan ^{[1
]}

Gu, Ting ^{[1
]}

Wu, Wen-Yu ^{[1
]}

Shi, Zhi-Hao ^{[2
]}

机构：

[1] Nanjing Univ Chinese Med, Jiangsu Collaborat Innovat Ctr Chinese Med Resour, Jiangsu Key Lab High Technol Res TCM Formulae, Natl Local Collaborat Engn Ctr Chinese Med Resour, Nanjing 210023, Jiangsu, Peoples R China

[2] China Pharmaceut Univ, Dept Organ Chem, Nanjing 211198, Jiangsu, Peoples R China

来源：

MOLECULES | 2016年 / 21卷 / 03期

基金：

中国国家自然科学基金;

关键词：

scutellarin; scutellarein; metabolite; efficient; synthesis; RATS; ISCHEMIA/REPERFUSION; THERAPY;

D O I：

10.3390/molecules21030263

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Scutellarein (2), which is an important in vivo metabolite of scutellarin (1), was synthesized from 3,4,5-trimethoxyphenol (3) in high yield in four steps. This strategy relies on acetylation, aldolization, cyclization and hydrolysis reactions, respectively.

引用

页数：4

共 9 条

[1]

[车庆明 CHE Qingming], 2006, [中国新药杂志, Chinese Journal New Drugs], V15, P1557

[2] Total synthesis of scutellarin-7-O-Glucuronide [J].