Lineage specification in innate lymphocytes

被引：10

作者：

Das, Arundhoti ^{[1
]}

Harly, Christelle ^{[1
]}

Yang, Qi ^{[2
]}

Bhandoola, Avinash ^{[1
]}

机构：

[1] NCI, Lab Genome Integr, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

[2] Albany Med Coll, Dept Immunol & Microbial Dis, Albany, NY 12208 USA

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2018年 / 42卷

关键词：

Innate lymphoid cells; ILC distribution; Central progenitors; Development; Homing; Peripheral ILC generation; TRANSCRIPTION FACTOR GATA3; LYMPHOID-CELL SUBSETS; TISSUE-INDUCER CELL; NK CELLS; HEMATOPOIETIC STEM; T-BET; EXTRAMEDULLARY HEMATOPOIESIS; PROGENITOR; IDENTIFICATION; PROMOTES;

D O I：

10.1016/j.cytogfr.2018.01.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Innate lymphoid cells (ILCs) are immune cells that lack specific antigen receptors but possess similar effector functions as T cells. Concordantly, ILCs express many transcription factors known to be important for T cell effector function. ILCs develop from lymphoid progenitors in fetal liver and adult bone marrow. However, the identification of ILC progenitor (ILCP) and other precursors in peripheral tissues raises the question of whether ILC development might occur at extramedullary sites. We discuss central and local generation in maintaining ILC abundance at peripheral sites.

引用

页码：20 / 26

页数：7

共 106 条

[1] Innate Immune Defenses Mediated by Two ILC Subsets Are Critical for Protection against Acute Clostridium difficile Infection [J].

Abt, Michael C. ;

Lewis, Brittany B. ;

Caballero, Silvia ;

Xiong, Huizhong ;

Carter, Rebecca A. ;

Susac, Boze ;

Ling, Lilan ;

Leiner, Ingrid ;

Pamer, Eric G. .

CELL HOST & MICROBE, 2015, 18 (01) :27-37

[2] The many roles of TOX in the immune system [J].

Aliahmad, Parinaz ;

Seksenyan, Akop ;

Kaye, Jonathan .

CURRENT OPINION IN IMMUNOLOGY, 2012, 24 (02) :173-177

[3] Shared dependence on the DNA-binding factor TOX for the development of lymphoid tissue-inducer cell and NK cell lineages [J].

Aliahmad, Parinaz ;

de la Torre, Brian ;

Kaye, Jonathan .

NATURE IMMUNOLOGY, 2010, 11 (10) :945-U98

[4] Identification and distribution of developing innate lymphoid cells in the fetal mouse intestine [J].

Bando, Jennifer K. ;

Liang, Hong-Erh ;

Locksley, Richard M. .

NATURE IMMUNOLOGY, 2015, 16 (02) :153-+

[5] The Residual Innate Lymphoid Cells in NFIL3-Deficient Mice Support Suboptimal Maternal Adaptations to Pregnancy [J].

Boulenouar, Selma ;

Doisne, Jean-Marc ;

Sferruzzi-Perri, Amanda ;

Gaynor, Louise M. ;

Kieckbusch, Jens ;

Balmas, Elisa ;

Yung, Hong Wa ;

Javadzadeh, Shagayegh ;

Volmer, Lea ;

Hawkes, Delia A. ;

Phillips, Keli ;

Brady, Hugh J. M. ;

Fowden, Abigail L. ;

Burton, Graham J. ;

Moffett, Ashley ;

Colucci, Francesco .

FRONTIERS IN IMMUNOLOGY, 2016, 7

[6]

Cardier JE, 1997, HEPATOLOGY, V26, P165

[7] Identification of the earliest NK-cell precursor in the mouse BM [J].

Carotta, Sebastian ;

Pang, Swee Heng Milon ;

Nutt, Stephen L. ;

Belz, Gabrielle T. .

BLOOD, 2011, 117 (20) :5449-5452

[8] Single-Cell Gene Expression Analyses Reveal Heterogeneous Responsiveness of Fetal Innate Lymphoid Progenitors to Notch Signaling [J].

Chea, Sylvestre ;

Schmutz, Sandrine ;

Berthault, Claire ;

Perchet, Thibaut ;

Petit, Maxime ;

Burlen-Defranoux, Odile ;

Goldrath, Ananda W. ;

Rodewald, Hans-Reimer ;

Cumano, Ana ;

Golub, Rachel .

CELL REPORTS, 2016, 14 (06) :1500-1516

[9] CXCR6 Expression Is Important for Retention and Circulation of ILC Precursors [J].

Chea, Sylvestre ;

Possot, Cecilie ;

Perchet, Thibaut ;

Petit, Maxime ;

Cumano, Ana ;

Golub, Rachel .

MEDIATORS OF INFLAMMATION, 2015, 2015

[10] Notch, Id2, and RORγt sequentially orchestrate the fetal development of lymphoid tissue inducer cells [J].

Cherrier, Marie ;

Sawa, Shinichiro ;

Eberl, Gerard .

JOURNAL OF EXPERIMENTAL MEDICINE, 2012, 209 (04) :729-740

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