HIV-induced decline in blood CD4/CD8 ratios: viral killing or altered lymphocyte trafficking?

被引：89

作者：

Rosenberg, YJ

Anderson, AO

Pabst, R

机构：

[1] TherImmune Inc, Rockville, MD 20852 USA

[2] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA

[3] Hannover Med Sch, Ctr Anat 4120, D-30623 Hannover, Germany

来源：

IMMUNOLOGY TODAY | 1998年 / 19卷 / 01期

关键词：

D O I：

10.1016/S0167-5699(97)01183-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

During HIV infection, CD4(+)-cell numbers and CD4/CD8 ratios decline in the blood. This is usually attributed to direct viral killing or to other indirect mechanisms. However, current models generally assume that such changes in the blood are representative of changes in total CD4(+)-cell numbers throughout the body. This article discusses the importance of alterations in CD4(+)- and CD8(+)-cell migration in regulating blood lymphocyte levels and questions the extent of virus-mediated CD4(+)-cell destruction.

引用

页码：10 / 17

页数：8

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