New tools for redox biology: From imaging to manipulation

被引：56
作者：
Bilan, Dmitry S. [1 ]
Belousov, Vsevolod V. [1 ]
机构：
[1] Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow, Russia
来源：
FREE RADICAL BIOLOGY AND MEDICINE | 2017年 / 109卷
基金：
俄罗斯基础研究基金会;
关键词：
Redox probes; HyPer; RoGFP; NAD; NADH; NADPH; Imaging; D-aminoacid oxidase; GREEN FLUORESCENT PROTEIN; NICOTINAMIDE-ADENINE-DINUCLEOTIDE; DISULFIDE BOND FORMATION; MITOCHONDRIAL INTERMEMBRANE SPACE; INTRACELLULAR HYDROGEN-PEROXIDE; OXYR TRANSCRIPTION FACTOR; SENSITIVE YFP SENSORS; MITOFLASH PROBE CPYFP; AMINO-ACID OXIDASE; OXIDATIVE STRESS;
D O I：
10.1016/j.freeradbiomed.2016.12.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Redox reactions play a key role in maintaining essential biological processes. Deviations in redox pathways result in the development of various pathologies at cellular and organismal levels. Until recently, studies on transformations in the intracellular redox state have been significantly hampered in living systems. The genetically encoded indicators, based on fluorescent proteins, have provided new opportunities in biomedical research. The existing indicators already enable monitoring of cellular redox parameters in different processes including embryogenesis, aging, inflammation, tissue regeneration, and pathogenesis of various diseases. In this review, we summarize information about all genetically encoded redox indicators developed to date. We provide the description of each indicator and discuss its advantages and limitations, as well as points that need to be considered when choosing an indicator for a particular experiment. One chapter is devoted to the important discoveries that have been made by using genetically encoded redox indicators.
引用
收藏
页码：167 / 188
页数：22
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