The role of kisspeptin system in cancer biology

被引：16
作者：
Stathaki, Martha [1 ]
Stamatiou, Maria Evanthia [1 ]
Magioris, George [1 ]
Simantiris, Spyridon [1 ]
Syrigos, L. Opdotoo Nikolaos [1 ]
Dourakis, Spyridon [2 ]
Koutsilieris, Michael [1 ]
Armakolas, Athanasios [1 ]
机构：
[1] Natl & Kapodestrian Univ Athens, Athens Med Sch, Physiol Lab, Athens, Greece
[2] Natl & Kapodistrian Univ Athens, Sch Med, Hippokrat Gen Hosp, Acad Dept Internal Med 2, Athens, Greece
来源：
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2019年 / 142卷
关键词：
Kisspeptin; KISS-1; KiSS-1R; Cancer; Metastases inhibition; METASTASIS SUPPRESSOR GENE; PROTEIN-COUPLED RECEPTOR; CELL LUNG-CANCER; BREAST-CANCER; TUMOR-METASTASIS; MECHANISTIC INSIGHTS; KISS-1; EXPRESSION; PLASMA KISSPEPTIN; MOLECULAR-BIOLOGY; MEDIATED TRANSFER;
D O I：
10.1016/j.critrevonc.2019.07.015
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Kisspeptins are a family of neuropeptides that are known to be critical in puberty initiation and ovulation. Apart from that kisspeptin derived peptides (KPs) are also known for their antimetastatic activities in several malignancies. Herein we report recent evidence of the role of kisspeptins in cancer biology and we examine the prospective of targeting the kisspeptin pathways leading to a better prognosis in patients with malignant diseases.
引用
收藏
页码：130 / 140
页数：11
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