Cardiovascular and Hepatic Toxicity of Cocaine: Potential Beneficial Effects of Modulators of Oxidative Stress

被引：23

作者：

Graziani, Manuela ^{[1
,2
]}

Antonilli, Letizia ^{[1
,2
]}

Togna, Anna Rita ^{[1
]}

Grassi, Maria Caterina ^{[1
,2
]}

Badiani, Aldo ^{[1
,3
]}

Saso, Luciano ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Dept Physiol & Pharmacol Vittorio Erspamer, Piazzale Aldo Moro 5, I-00185 Rome, Italy

[2] Univ Roma La Sapienza, Univ Hosp Umberto 1, Drug Addict & Clin Pharmacol Unit, Piazzale Aldo Moro 5, I-00185 Rome, Italy

[3] Univ Sussex, Sch Psychol, Sussex Addict Res & Intervent Ctr, Brighton BN1 9RH, E Sussex, England

来源：

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2016年 / 2016卷

关键词：

ENDOTHELIUM-DEPENDENT VASORELAXATION; NITRIC-OXIDE SYNTHASE; N-ACETYLCYSTEINE; NADPH OXIDASES; INDUCED HEPATOTOXICITY; MYOCARDIAL-INFARCTION; SUPEROXIDE-DISMUTASE; PLATELET ACTIVATION; XANTHINE-OXIDASE; IN-VITRO;

D O I：

10.1155/2016/8408479

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Oxidative stress (OS) is thought to play an important role in the pharmacological and toxic effects of various drugs of abuse. Herein we review the literature on the mechanisms responsible for the cardiovascular and hepatic toxicity of cocaine with special focus on OS-related mechanisms. We also review the preclinical and clinical literature concerning the putative therapeutic effects of OS modulators (such as N-acetylcysteine, superoxide dismutase mimetics, nitroxides and nitrones, NADPH oxidase inhibitors, xanthine oxidase inhibitors, and mitochondriotropic antioxidants) for the treatment of cocaine toxicity. We conclude that available OS modulators do not appear to have clinical efficacy.

引用

页数：14

共 197 条

[21] Effects of cocaine and its oxidative metabolites on mitochondrial respiration and generation of reactive oxygen species [J].