The effect of β-cyclodextrin on the Formation of Phospholipid Micelles: A Molecular Dynamics Simulation Study

被引：0
|
作者：
Makiela, D. [1 ]
Gorny, K. [1 ]
Gburski, Z. [1 ,2 ]
机构：
[1] Univ Silesia, Inst Phys, Silesian Ctr Educ & Interdisciplinary Res, Katowice, Poland
[2] Katowice Inst Informat Technol, Mickiewicza 29, PL-40085 Katowice, Poland
来源：
ACTA PHYSICA POLONICA A | 2019年 / 136卷 / 03期
关键词：
LIGHT-SCATTERING; X-RAY; CHOLESTEROL; DMPC; ENVIRONMENT; MEMBRANES; BOUNDARY; WATER; SIZE;
D O I：
10.12693/APhysPolA.136.542
中图分类号：
O4 [物理学];
学科分类号：
0702 ;
摘要：
Using the molecular dynamics simulation method we studied the aqueous solution of beta-cyclodextrin and 1,2-dimyristoyl-sn-glycero-3phosphocholine (DMPC) molecules. We observed that in water environment DMPC molecules form a "core" surrounded by beta-cyclodextrins which stick to the surface of DMPC core. The developed beta-cyclodextrin shell (corona) might facilitate the transport of DMPC cluster in bioenvironment. Moreover some smaller binary complexes, composed of only single pair of beta-cyclodextrin and DMPC were detected. Our simulations showed that beta-cyclodextrin do not influence the structure of lipid aggregates and should not negatively interfere the liposomal drug delivery systems.
引用
收藏
页码：542 / 547
页数：6
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