The role of prolactin in mammary carcinoma

被引:434
作者
Clevenger, CV [1 ]
Furth, PA
Hankinson, SE
Schuler, LA
机构
[1] Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA
[2] Georgetown Univ, Vincent T Lombardi Canc Res Ctr, Dept Oncol, Washington, DC 20057 USA
[3] Brigham & Womens Hosp, Dept Med, Channing Labs, Boston, MA 02115 USA
[4] Harvard Univ, Sch Med, Cambridge, MA 02115 USA
[5] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Cambridge, MA 02115 USA
[6] Univ Wisconsin, Dept Comparat Biosci, Madison, WI 53706 USA
关键词
D O I
10.1210/er.2001-0036
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The contribution of prolactin (PRL) to the pathogenesis and progression of human breast cancer at the cellular, transgenic, and epidemiological levels is increasingly appreciated. Acting at the endocrine and autocrine/paracrine levels, PRL functions to stimulate the growth and motility of human breast cancer cells. The actions of this ligand are mediated by at least six recognized PRL receptor isoforms found on, or secreted by, human breast epithelium. The PRL/PRL receptor complex associates with and activates several signaling net-works that are shared with other members of the cytokine receptor superfamily. Coupled with the recently identified intranuclear function of PRL, these networks are integrated into the in vitro and in vivo actions induced by ligand. These findings indicate that antagonists of PRL/PRL receptor interaction or PRL receptor-associated signal transduction may be of considerable utility in the treatment of human breast cancer.
引用
收藏
页码:1 / 27
页数:27
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