Screening for Syphilis Infection in Nonpregnant Adults and Adolescents US Preventive Services Task Force Recommendation Statement

被引:101
作者
Bibbins-Domingo, Kirsten [1 ]
Grossman, David C. [2 ]
Curry, Susan J. [3 ]
Davidson, Karina W. [4 ]
Epling, John W., Jr. [5 ]
Garcia, Francisco A. R. [6 ]
Gillman, Matthew W. [7 ,8 ]
Harper, Diane M. [9 ]
Kemper, Alex R. [10 ]
Krist, Alex H. [11 ,12 ]
Kurth, Ann E. [13 ]
Landefeld, C. Seth [14 ]
Mangione, Carol M. [15 ]
Phillips, William R. [16 ]
Phipps, Maureen G. [17 ]
Pignone, Michael P. [18 ]
机构
[1] Univ Calif San Francisco, San Francisco, CA 94143 USA
[2] Grp Hlth Res Inst, Seattle, WA USA
[3] Univ Iowa, Iowa City, IA USA
[4] Columbia Univ, New York, NY USA
[5] SUNY Upstate Med Univ, Syracuse, NY 13210 USA
[6] Pima Cty Dept Hlth, Tucson, AZ USA
[7] Harvard Univ, Sch Med, Boston, MA USA
[8] Harvard Pilgrim Hlth Care Inst, Boston, MA USA
[9] Univ Louisville, Louisville, KY 40292 USA
[10] Duke Univ, Durham, NC USA
[11] Fairfax Family Practice, Fairfax, VA USA
[12] Virginia Commonwealth Univ, Richmond, VA 23284 USA
[13] Yale Univ, New Haven, CT USA
[14] Univ Alabama Birmingham, Birmingham, AL USA
[15] Univ Calif Los Angeles, Los Angeles, CA USA
[16] Univ Washington, Seattle, WA 98195 USA
[17] Brown Univ, Providence, RI 02912 USA
[18] Univ N Carolina, Chapel Hill, NC USA
来源
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | 2016年 / 315卷 / 21期
基金
美国医疗保健研究与质量局;
关键词
CD4 CELL COUNTS; HIV VIRAL LOAD; POPULATION; GUIDELINES;
D O I
10.1001/jama.2016.5824
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
IMPORTANCE In 2014, 19 999 cases of syphilis were reported in the United States. Left untreated, syphilis can progress to late-stage disease in about 15% of persons who are infected. Late-stage syphilis can lead to development of inflammatory lesions throughout the body, which can lead to cardiovascular or organ dysfunction. Syphilis infection also increases the risk for acquiring or transmitting HIV infection. OBJECTIVE To update the 2004 US Preventive Services Task Force (USPSTF) recommendation on screening for syphilis infection in nonpregnant adults. Screening for syphilis in pregnant women was updated in a separate recommendation statement in 2009 (A recommendation). EVIDENCE REVIEW The USPSTF reviewed the evidence on screening for syphilis infection in asymptomatic, nonpregnant adults and adolescents, including patients coinfected with other sexually transmitted infections (such as HIV). FINDINGS The USPSTF found convincing evidence that screening for syphilis infection in asymptomatic, nonpregnant persons at increased risk for infection provides substantial benefit. Accurate screening tests are available to identify syphilis infection in populations at increased risk. Effective treatment with antibiotics can prevent progression to late-stage disease, with small associated harms, providing an overall substantial health benefit. CONCLUSIONS AND RECOMMENDATION The USPSTF recommends screening for syphilis infection in persons who are at increased risk for infection. (A recommendation)populations
引用
收藏
页码:2321 / 2327
页数:7
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