Analytically validated protein biomarkers of chronic pancreatitis and pancreatic cancer for potential clinical diagnosis with mass spectrometry

被引：4

作者：

Chou, Che-Yi ^{[1
,2
]}

Chang, Chiz-Tzung ^{[3
,4
,5
]}

Chen, Chao-Jung ^{[6
,7
]}

机构：

[1] Asia Univ Hosp, Div Nephrol, Taichung, Taiwan

[2] Asia Univ, Dept Postbaccalaureate Vet Med, Taichung, Taiwan

[3] China Med Univ, Coll Med, Taichung, Taiwan

[4] China Med Univ Hosp, Kidney Inst, Dept Internal Med, Taichung 40447, Taiwan

[5] China Med Univ Hosp, Div Nephrol, Dept Internal Med, Taichung 40447, Taiwan

[6] China Med Univ Hosp, Dept Med Res, Prote Core Lab, Taichung 40402, Taiwan

[7] China Med Univ, Grad Inst Integrated Med, 91 Hsueh Shih Rd, Taichung 40402, Taiwan

来源：

RAPID COMMUNICATIONS IN MASS SPECTROMETRY | 2020年 / 34卷

关键词：

DATA-INDEPENDENT ACQUISITION; FECAL ELASTASE-1; DUCTAL ADENOCARCINOMA; TISSUE INHIBITOR; PROTEOMICS; IDENTIFICATION; YKL-40; CHOLANGIOPANCREATOGRAPHY; QUANTIFICATION; QUANTITATION;

D O I：

10.1002/rcm.8580

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Rationale Chronic pancreatitis (CP) is a pancreatic disease with poor prognosis and pancreatic cancer (PC) is one of the most lethal types of cancer that is symptomless in the early stage. Because the clinical and image findings of CP can overlap that of pancreatic cancer (PC) which leads to confusion in the diagnosis and treatment of PC, discovery/verification/validation of more accurate protein biomarkers to diagnose CP and PC is in urgent need. Methods The PubMed, Web of Science, and Google Scholar were searched using the keywords: 'biomarker', 'marker', 'chronic pancreatitis', "pancreatic cancer" or "proteomics" for highly related researches. We focused on the articles published after the year 2005 in this review. Results We introduce the background to CP and PC and summarize the diagnosis of CP and PC, analytically validated protein biomarkers, and proteomic approaches for discovery/verification/validation. The potential use of mass spectrometry (MS) in clinical diagnosis is also discussed. Conclusions Continuously improving sensitivity of MS can provide deeper proteome for new marker discovery and high reliability for protein marker verification, validation, and clinical diagnosis. The analytically validated protein markers could be considered as targeted protein biomarkers for developing a MS platform in the clinical validation process or clinical diagnosis of CP and PC.

引用

页数：9

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