Synthesis and enantioseparation characteristics of a novel β-cyclodextrin chiral stationary phase based on diazotized silica in HPLC

被引：1
作者：
Tang, Qi [1 ,2 ]
He, Long-Xiang [2 ]
Chu, Xiao-Kun [2 ]
Yu, Bing [2 ,3 ]
Gu, Xiang-Ling [1 ]
Shen, You-Qing [2 ]
Cong, Hai-Lin [2 ,3 ]
机构：
[1] Dezhou Univ, Coll Chem & Chem Engn, Dezhou, Peoples R China
[2] Qingdao Univ, Coll Mat Sci & Engn, Inst Biomed Mat & Engn, Qingdao, Peoples R China
[3] Qingdao Univ, State Key Lab Biofibers & Ecotext, Qingdao, Peoples R China
来源：
FERROELECTRICS | 2021年 / 579卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Diazoresin; silica microspheres; beta-cyclodextrin; liquid chromatography; PERFORMANCE; CAPILLARY;
D O I：
10.1080/00150193.2021.1903260
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
A novel chiral selector polyacrylic acid-beta-cyclodextrin (PAA-beta-CD) was successfully prepared, then a facile synthesis of PAA-beta-CD stationary phase based on diazotized silica was developed and characterized. Monodisperse silica microspheres were synthesized by a modified Stober method. The obtained silica particles were functionalized by self-assembly positive charged photosensitive diazoresin (DR) and PAA-beta-CD on the surface. The corresponding chiral stationary phase (CSP) was used in HPLC and the enantioseparation performance was investigated in both polar organic and reverse phase mode. Better separation abilities and excellent enantio-selectivities were obtained on PAA-beta-CD CSP for antihistamine drugs in the acetonitrile and triethylammonium acetate buffer mobile phase.
引用
收藏
页码：199 / 208
页数：10
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