Effect of the emulsion of Sacha Inchi (Plukenetia huayabambana) oil on oxidative stress and inflammation in rats induced to obesity

被引：19

作者：

Ambulay, Johnny P. ^{[1
]}

Rojas, Percy A. ^{[3
]}

Timoteo, Olga S. ^{[2
]}

Barreto, Teresa, V ^{[3
]}

Colarossi, Ana ^{[1
]}

机构：

[1] Univ Peruana Cayetano Heredia, Micronutrients Lab, Labs Res & Dev, Av Honorio Delgado 430, Lima 31, Peru

[2] Bioincuba, Calle Jose Antonio N310 Urb Camacho, Lima 12, Peru

[3] Univ Peruana Cayetano Heredia, Labs Res & Dev, Unit Mol Biotechnol, Av Honorio Delgado 430, Lima 31, Peru

来源：

JOURNAL OF FUNCTIONAL FOODS | 2020年 / 64卷

关键词：

Obesity; Lipid profile; Oxidative stress; Inflammation; Sacha Inchi; ALPHA-LINOLENIC ACID; POLYUNSATURATED FATTY-ACIDS; ISCHEMIA-REPERFUSION INJURY; RICH FLAXSEED OIL; PROTEIN PRODUCTS; N-3; LCPUFA; ADIPOCYTE DIFFERENTIATION; CARDIOVASCULAR-DISEASE; LIPID-PEROXIDATION; ANTIOXIDANT POWER;

D O I：

10.1016/j.jff.2019.103631

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Sacha Inchi (Plukenetia huayllabambana), an oleoleguminosae with a high content omega-3, could help normalize alterations of obesity. We evaluated the effect of emulsion of Sacha Inchi (SI) oil on the lipid profile, oxidative stress and inflammation in serum and liver tissue of obesity-induced rats. Five groups induced to obesity by high-fat diet were analyzed. One group without treatment, two groups with the emulsion of SI oil (OSI1:0.25 omega-3/day, OSI2:0.5 omega-3/day), one group with atorvastatin and one group with atorvastatin plus the emulsion of SI oil. The treated groups lowered the values of total cholesterol, triglycerides, and LDLc, and increased HDLc. The lipid and protein oxidation marker, IL-6 and leptin decreased in serum, as well as TNF-alpha hepatic. In contrast, serum adiponectin, antioxidant capacity, and liver catalase activity increased in the OSI2 group. Therefore, the emulsion of SI oil normalizes the lipid profile and decreases oxidative stress and inflammation in an obesity model.

引用

页数：9

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