Novel functionalized pyridine-containing DTPA-like ligand.: Synthesis, computational studies and characterization of the corresponding GdIII complex

被引：11
作者：
Artali, Roberto
Botta, Mauro
Cavallotti, Camilla
Giovenzana, Giovanni B.
Palmisano, Giovanni
Sisti, Massimo
机构：
[1] Univ Piemonte Orientale, Dipartimento Sci Ambiente & Vita, I-15100 Alessandria, Italy
[2] Univ Milan, Ist Chim Farmaceut & Tossicol Pietro Pratesi, I-20131 Milan, Italy
[3] CAGE Chem, I-10135 Turin, Italy
[4] Univ Piemonte Orientale, Dipartimento Sci Chim Alimentari Farmaceut & Farm, I-28100 Novara, Italy
[5] Univ Piemonte Orientale, DFB Ctr, I-28100 Novara, Italy
[6] Univ Insubria, Dipartimento Sci Chim & Ambientali, I-22100 Como, Italy
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2007年 / 5卷 / 15期
关键词：
D O I：
10.1039/b706236b
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel pyridine-containing DTPA-like ligand, carrying additional hydroxymethyl groups on the pyridine side-arms, was synthesized in 5 steps. The corresponding Gd-III complex, potentially useful as an MRI contrast agent, was prepared and characterized in detail by relaxometric methods and its structure modeled by computational methods.
引用
收藏
页码：2441 / 2447
页数：7
相关论文
共 41 条
[1]   A review on the use of sodium triacetoxyborohydride in the reductive amination of ketones and aldehydes [J].
Abdel-Magid, Ahmed F. ;
Mehrman, Steven J. .
ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2006, 10 (05) :971-1031
[2]   Reductive amination of aldehydes and ketones with sodium triacetoxyborohydride. Studies on direct and indirect reductive amination procedures [J].
AbdelMagid, AF ;
Carson, KG ;
Harris, BD ;
Maryanoff, CA ;
Shah, RD .
JOURNAL OF ORGANIC CHEMISTRY, 1996, 61 (11) :3849-3862
[3]   Gd(III)-based contrast agents for MRI [J].
Aime, S ;
Botta, M ;
Terreno, E .
ADVANCES IN INORGANIC CHEMISTRY - INCLUDING BIOINORGANIC STUDIES, VOL 57: RELAXOMETRY OF WATER-METAL ION INTERACTIONS, 2005, 57 :173-237
[4]   NMR, relaxometric, and structural studies of the hydration and exchange dynamics of cationic lanthanide complexes of macrocyclic tetraamide ligands [J].
Aime, S ;
Barge, A ;
Bruce, JI ;
Botta, M ;
Howard, JAK ;
Moloney, JM ;
Parker, D ;
de Sousa, AS ;
Woods, M .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (24) :5762-5771
[5]   Prototropic and water-exchange processes in aqueous solutions of Gd(III) chelates [J].
Aime, S ;
Botta, M ;
Fasano, M ;
Terreno, E .
ACCOUNTS OF CHEMICAL RESEARCH, 1999, 32 (11) :941-949
[6]  
[Anonymous], 2001, ACOUSTIC CHARACTERIZ
[7]  
Bunzli J. C. G., 1989, LANTHANIDE PROBES LI
[8]   Taking advantage of luminescent lanthanide ions [J].
Bünzli, JCG ;
Piguet, C .
CHEMICAL SOCIETY REVIEWS, 2005, 34 (12) :1048-1077
[9]   Gadolinium(III) chelates as MRI contrast agents: Structure, dynamics, and applications [J].
Caravan, P ;
Ellison, JJ ;
McMurry, TJ ;
Lauffer, RB .
CHEMICAL REVIEWS, 1999, 99 (09) :2293-2352
[10]   Cationic lanthanide complexes of N,N'-bis(2-pyridylmethyl)ethylenediamine-N,N'-diacetic acid (H(2)bped) [J].
Caravan, P ;
Mehrkhodavandi, P ;
Orvig, C .
INORGANIC CHEMISTRY, 1997, 36 (07) :1316-1321
12345