Elevated serum β-defensins concentrations in patients with lung cancer

Background: Beta-defensins (HBDs) are expressed in lung epithelial cells and act as antimicrobial agents. Most lung cancers that originate from pulmonary epithelial cells may produce HBDs. Materials and Methods: We measured serum HBD-1 and HBD-2 levels in healthy subjects (HS), patients with lung cancer and patients with pneumonia by radioimmunoassay. Results: Serum HBD-1 levels were higher in patients with lung cancer than HS and patients with pneumonia. Serum HBD-2 levels were higher in patients with lung cancer than HS. When cut-off values for positive HBD- were set at mean + 2SD of HS, the sensitivity and specificity of HBD-1 for the whole group of patients with lung cancer were 76.4 and 94.0 %, respectively, and the proportion of patients with HBD-1-positive lung cancer and clinical stage I was 69.2 %. Conclusion: Serum HBDs levels were high in patients with lung cancer and the serum HBD-1 level could be used as an auxiliary); diagnostic tool for lung cancer.