Diversity within the DRB1*08 allele family in four populations from a United States hematopoietic stem cell donor database and characterization of five novel DRB1*08 alleles

被引：4
作者：
Rizzuto, G
Li, L
Steiner, N
Slack, R
Tang, T
Heine, U
Lin, YS
Ng, J
Hartzman, RJ
Hurley, CK
机构：
[1] Georgetown Univ, Med Ctr, Dept Oncol, Washington, DC 20057 USA
[2] Georgetown Univ, Med Ctr, Dept Pediat, Washington, DC 20057 USA
[3] Lab Corp Amer, Burlington, NC USA
[4] Natl Naval Med Ctr, Kensington, MD USA
来源：
HUMAN IMMUNOLOGY | 2003年 / 64卷 / 06期
关键词：
HLA-DR8; allele frequency; DNA sequencing;
D O I：
10.1016/S0198-8859(03)00069-7
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The frequencies of DRB 1*08 alleles within four major United States populations found within a hematopoietic stem cell volunteer donor database were determined by DNA sequencing of over 60 DRB1*08 positive individuals from each group. Seven of 30 known DRB1*08 alleles were identified within this study population (080101, 080201, 080302, 080401, 0806, 0807, and 0811). Each ethnic group was characterized by a different highly prevalent allele: DRB1*080101 in Caucasians; DRB1*080401 in African-Americans; DRB1* 080302 in Asians; and DRB1*080201 in Hispanics. The alleles DRB1*080101, DRB1*080201, and DRB1* 080401 were present in all four populations. This report also describes five novel DRB1*08 alleles uncovered during routine human leukocyte antigen typing. (C) American Society for Histocompatibility and Immunogenetics, 2003. Published by Elsevier Inc.
引用
收藏
页码：607 / 613
页数：7
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