Emergence of Carbapenemase-Producing Enterobacteriaceae, South-Central Ontario, Canada

被引：22
|
作者：
Kohler, Philipp P. [1 ,18 ]
Melano, Roberto G. [2 ,3 ]
Patel, Samir N. [2 ,3 ]
Shafinaz, Shumona [1 ]
Faheem, Amna [1 ]
Coleman, Brenda L. [1 ,3 ]
Green, Karen [1 ]
Armstrong, Irene [3 ,4 ]
Almohri, Huda [5 ]
Borgia, Sergio [6 ,7 ]
Borgundvaag, Emily [1 ]
Johnstone, Jennie [3 ,8 ,9 ]
Katz, Kevin [3 ,9 ,10 ]
Lam, Freda [9 ]
Muller, Matthew P. [3 ,11 ]
Powis, Jeff [3 ,12 ]
Poutanen, Susan M. [1 ,3 ,13 ]
Richardson, David [7 ]
Rebbapragada, Anu [14 ]
Sarabia, Alicia [3 ,15 ,16 ]
Simor, Andrew [3 ,17 ]
McGeer, Allison [1 ,3 ]
机构：
[1] Sinai Hlth Syst, Toronto, ON, Canada
[2] Publ Hlth Ontario Labs, Toronto, ON, Canada
[3] Univ Toronto, Toronto, ON, Canada
[4] Toronto Publ Hlth, Toronto, ON, Canada
[5] LifeLabs, Toronto, ON, Canada
[6] McMaster Univ, Hamilton, ON, Canada
[7] William Osler Hlth Syst, Brampton, ON, Canada
[8] St Josephs Hlth Ctr, Toronto, ON, Canada
[9] Publ Hlth Ontario, Toronto, ON, Canada
[10] North York Gen Hosp, Toronto, ON, Canada
[11] St Michaels Hosp, Toronto, ON, Canada
[12] Toronto East Hlth Network, Toronto, ON, Canada
[13] Univ Hlth Network, Toronto, ON, Canada
[14] Dynacare, Brampton, ON, Canada
[15] Trillium Hlth Partners, Toronto, ON, Canada
[16] Trillium Hlth Partners, Mississauga, ON, Canada
[17] Sunnybrook Hlth Sci Ctr, Toronto, ON, Canada
[18] Cantonal Hosp, St Gallen, Switzerland
来源：
EMERGING INFECTIOUS DISEASES | 2018年 / 24卷 / 09期
基金：
美国国家科学基金会;
关键词：
INFECTION SURVEILLANCE PROGRAM; KLEBSIELLA-PNEUMONIAE; RESISTANT ENTEROBACTERIACEAE; SPREAD; EPIDEMIOLOGY; ORGANISMS;
D O I：
10.3201/eid2409.180164
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We analyzed population-based surveillance data from the Toronto Invasive Bacterial Diseases Network to describe carbapenemase-producing Enterobacteriaceae (CPE) infections during 2007-2015 in south-central Ontario, Canada. We reviewed patients' medical records and travel histories, analyzed microbiologic and clinical characteristics of CPE infections, and calculated incidence. Among 291 cases identified, New Delhi metallo-beta-lactamase was the predominant carbapenemase (51%). The proportion of CPE-positive patients with prior admission to a hospital in Canada who had not received healthcare abroad or traveled to high-risk areas was 13% for patients with oxacillinase-48, 24% for patients with New Delhi metallo-beta-lactamase, 55% for patients with Klebsiella pneumoniae carbapenemase, and 67% for patients with Verona integron-encoded metallo-beta-lactamase. Incidence of CPE infection increased, reaching 0.33 cases/100,000 population in 2015. For a substantial proportion of patients, no healthcare abroad or high-risk travel could be established, suggesting CPE acquisition in Canada. Policy and practice changes are needed to mitigate nosocomial CPE transmission in hospitals in Canada.
引用
收藏
页码：1674 / 1682
页数：9
相关论文
共 50 条
  • [1] Emergence of carbapenemase-producing Enterobacteriaceae in Malawi
    Lewis, Joseph M.
    Lester, Rebecca
    Mphasa, Madalitso
    Banda, Rachel
    Edwards, Thomas
    Thomson, Nicholas R.
    Feasey, Nicholas
    JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE, 2020, 20 : 225 - 227
  • [2] Carbapenemase-Producing Enterobacteriaceae
    Doi, Yohei
    Paterson, David L.
    SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE, 2015, 36 (01) : 74 - 84
  • [3] Rapid emergence of carbapenemase-producing Enterobacteriaceae isolates in Belgium
    Huang, T-D
    Bogaerts, P.
    Berhin, C.
    Jans, B.
    Deplano, A.
    Denis, O.
    Glupczynski, Y.
    EUROSURVEILLANCE, 2011, 16 (26) : 8 - 10
  • [4] Emergence of carbapenemase-producing Enterobacteriaceae in France, 2004 to 2011
    Vaux, S.
    Carbonne, A.
    Thiolet, J. M.
    Jarlier, V.
    Coignard, B.
    EUROSURVEILLANCE, 2011, 16 (22): : 11 - 17
  • [5] Household Transmission of Carbapenemase-producing Enterobacterales in Ontario, Canada
    Jamal, Alainna J.
    Faheem, Amna
    Farooqi, Lubna
    Zhong, Xi Zoe
    Armstrong, Irene
    Boyd, David A.
    Borgundvaag, Emily
    Coleman, Brenda L.
    Green, Karen
    Jayasinghe, Kithsiri
    Johnstone, Jennie
    Katz, Kevin
    Kohler, Philipp
    Li, Angel X.
    Mataseje, Laura
    Melano, Roberto
    Muller, Matthew P.
    Mulvey, Michael R.
    Nayani, Sarah
    Patel, Samir N.
    Paterson, Aimee
    Poutanen, Susan
    Rebbapragada, Anu
    Richardson, David
    Sarabia, Alicia
    Shafinaz, Shumona
    Simor, Andrew E.
    Willey, Barbara M.
    Wisely, Laura
    McGeer, Allison J.
    CLINICAL INFECTIOUS DISEASES, 2021, 73 (11) : E4607 - E4615
  • [6] Carbapenemase-producing Enterobacterales in hospital drains in Southern Ontario, Canada
    Jamal, A. J.
    Mataseje, L. F.
    Brown, K. A.
    Katz, K.
    Johnstone, J.
    Muller, M. P.
    Allen, V. G.
    Borgia, S.
    Boyd, D. A.
    Ciccotelli, W.
    Delibasic, K.
    Fisman, D. N.
    Khan, N.
    Leis, J. A.
    Li, A. X.
    Mehta, M.
    Ng, W.
    Pantelidis, R.
    Paterson, A.
    Pikula, G.
    Sawicki, R.
    Schmidt, S.
    Souto, R.
    Tang, L.
    Thomas, C.
    McGeer, A. J.
    Mulvey, M. R.
    JOURNAL OF HOSPITAL INFECTION, 2020, 106 (04) : 820 - 827
  • [7] Emergence and Rapid Regional Spread of Klebsiella pneumoniae Carbapenemase-Producing Enterobacteriaceae
    Won, Sarah Y.
    Munoz-Price, L. Silvia
    Lolans, Karen
    Hota, Bala
    Weinstein, Robert A.
    Hayden, Mary K.
    CLINICAL INFECTIOUS DISEASES, 2011, 53 (06) : 532 - 540
  • [8] Carbapenemase-producing Enterobacteriaceae: a call for action!
    Nordmann, P.
    Cornaglia, G.
    CLINICAL MICROBIOLOGY AND INFECTION, 2012, 18 (05) : 411 - 412
  • [9] Identification and screening of carbapenemase-producing Enterobacteriaceae
    Nordmann, P.
    Gniadkowski, M.
    Giske, C. G.
    Poirel, L.
    Woodford, N.
    Miriagou, V.
    CLINICAL MICROBIOLOGY AND INFECTION, 2012, 18 (05) : 432 - 438
  • [10] The global epidemiology of carbapenemase-producing Enterobacteriaceae
    van Duin, David
    Doi, Yohei
    VIRULENCE, 2017, 8 (04) : 460 - 469
12345