Moving Forward: Recent Developments for the Ferret Biomedical Research Model

被引：53

作者：

Albrecht, Randy A. ^{[1
]}

Liu, Wen-Chun ^{[1
]}

Sant, Andrea J. ^{[2
]}

Tompkins, S. Mark ^{[3
]}

Pekosz, Andrew ^{[4
]}

Meliopoulos, Victoria ^{[5
]}

Cherry, Sean ^{[5
]}

Thomas, Paul G. ^{[6
]}

Schultz-Cherry, Stacey ^{[5
]}

机构：

[1] Icahn Sch Med Mt Sinai, Dept Microbiol, New York, NY 10029 USA

[2] Univ Rochester, Med Ctr, Dept Microbiol & Immunol, David H Smith Ctr Vaccine Biol & Immunol, Rochester, NY 14642 USA

[3] Univ Georgia, Ctr Vaccines & Immunol, Athens, GA 30602 USA

[4] Johns Hopkins Univ, W Harry Feinstone Dept Mol Microbiol & Immunol, Bloomberg Sch Publ Hlth, Baltimore, MD USA

[5] St Jude Childrens Res Hosp, Dept Immunol, 332 N Lauderdale St, Memphis, TN 38105 USA

[6] St Jude Childrens Res Hosp, Dept Infect Dis, 332 N Lauderdale St, Memphis, TN 38105 USA

来源：

MBIO | 2018年 / 9卷 / 04期

关键词：

advances; animal model; ferret; INFLUENZA-VIRUS INFECTION; MUSTELA-PUTORIUS-FURO; CLONED FERRETS; VACCINE; RESPONSES; DISEASE; HEALTHY; CELLS;

D O I：

10.1128/mBio.01113-18

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Since the initial report in 1911, the domestic ferret has become an invaluable biomedical research model. While widely recognized for its utility in influenza virus research, ferrets are used for a variety of infectious and noninfectious disease models due to the anatomical, metabolic, and physiological features they share with humans and their susceptibility to many human pathogens. However, there are limitations to the model that must be overcome for maximal utility for the scientific community. Here, we describe important recent advances that will accelerate biomedical research with this animal model.

引用

页数：5

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