Cutaneous MelanomaA Long Road from Experimental Models to Clinical Outcome: A Review

被引：56

作者：

Coricovac, Dorina ^{[1
]}

Dehelean, Cristina ^{[1
]}

Moaca, Elena-Alina ^{[1
]}

Pinzaru, Iulia ^{[1
]}

Bratu, Tiberiu ^{[2
]}

Navolan, Dan ^{[3
]}

Boruga, Ovidiu ^{[2
]}

机构：

[1] Victor Babes Univ Med & Pharm, Dept Toxicol, Fac Pharm, Timisoara 300041, Romania

[2] Victor Babes Univ Med & Pharm, Fac Med, Timisoara 300041, Romania

[3] Victor Babes Univ Med & Pharm, Fac Med, Dept Obstet Gynecol & Neonatol, Timisoara 300041, Romania

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 06期

关键词：

cutaneous melanoma; incidence; etiology; animal models; genetic profile; TRANSGENIC MOUSE MODEL; TUMOR-DEVELOPMENT; INCIDENCE RATES; SEX-DIFFERENCES; IN-VITRO; SKIN; MELANOGENESIS; PATHWAYS; EXPRESSION; MICE;

D O I：

10.3390/ijms19061566

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cutaneous melanoma is a complex disorder characterized by an elevated degree of heterogeneity, features that place it among the most aggressive types of cancer. Although significant progress was recorded in both the understanding of melanoma biology and genetics, and in therapeutic approaches, this malignancy still represents a major problem worldwide due to its high incidence and the lack of a curative treatment for advanced stages. This review offers a survey of the most recent information available regarding the melanoma epidemiology, etiology, and genetic profile. Also discussed was the topic of cutaneous melanoma murine models outlining the role of these models in understanding the molecular pathways involved in melanoma initiation, progression, and metastasis.

引用

页数：18

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