Intracranially recorded ictal direct current shifts may precede high frequency oscillations in human epilepsy

被引：66

作者：

Kanazawa, Kyoko ^{[2
]}

Matsumoto, Riki ^{[1
]}

Imamura, Hisaji ^{[2
]}

Matsuhashi, Masao ^{[3
]}

Kikuchi, Takayuki ^{[4
]}

Kunieda, Takeharu ^{[4
]}

Mikuni, Nobuhiro ^{[5
]}

Miyamoto, Susumu ^{[4
]}

Takahashi, Ryosuke ^{[2
]}

Ikeda, Akio ^{[1
]}

机构：

[1] Kyoto Univ, Dept Epilepsy Movement Disorders & Physiol, Kyoto, Japan

[2] Kyoto Univ, Dept Neurol, Kyoto, Japan

[3] Kyoto Univ, Human Brain Res Ctr, Kyoto, Japan

[4] Kyoto Univ, Dept Neurosurg, Kyoto, Japan

[5] Sapporo Med Univ, Dept Neurol Surg, Sapporo, Hokkaido, Japan

来源：

CLINICAL NEUROPHYSIOLOGY | 2015年 / 126卷 / 01期

关键词：

DC shift; High-frequency oscillation; Epilepsy; Glioma; Focal cortical dysplasia; Infraslow activity; INFRASLOW ACTIVITY; SEIZURE ONSET; NEOCORTICAL EPILEPSY; BRAIN; EEG; MECHANISMS; LOCALIZATION; HZ; HIPPOCAMPAL; ASTROCYTES;

D O I：

10.1016/j.clinph.2014.05.028

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: We assessed the temporal-spatial characteristics of ictal direct current (DC) shifts (or infraslow activity) and high frequency oscillations (HFOs) in 16 patients with intractable focal epilepsy. Methods: The underlying etiology consisted of cortical dysplasia, glioma, hippocampal sclerosis, and low-grade neuroepithelial tumor in nine, four, two, and one patients, respectively. The median number of analyzed seizure events was 8.0 per patient (range: 2-10). Chronic electrocorticographic recording was performed with (1) a band-pass filter of 0.016-600 Hz (or 0.016-300 Hz) and a sampling rate of 2000 Hz (or 1000 Hz). Results: Ictal DC shifts and a sustained form of ictal HFOs were observed in 75.0% and 50.0% of the patients, and 71.3% and 46.3% of the analyzed seizures. Visual assessment revealed that the onset of ictal DC shifts preceded that of ictal HFOs with statistical significance in 5/7 patients. The spatial extent of ictal DC shifts or HFOs was smaller than that of the conventionally defined seizure onset zone in 9/12 patients. Conclusion: Both ictal DC shifts and HFOs might represent the core of tissue generating seizures. Significance: The early occurrence of ictal DC shifts warrants further studies to determine the role of glia (possibly mediating ictal DC shifts) in seizure generation. (C) 2014 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

引用

页码：47 / 59

页数：13

共 56 条

[1]

[Anonymous], 1999, ELECTROENCEPHALOGRAP

[2] EXCITABILITY CHANGES AND INHIBITORY MECHANISMS IN NEOCORTICAL NEURONS DURING SEIZURES [J].

AYALA, GF ;

MATSUMOTO, H ;

GUMNIT, RJ .

JOURNAL OF NEUROPHYSIOLOGY, 1970, 33 (01) :73-+

[3] Astrocyte-neuron interactions Implications for epilepsy [J].

Benarroch, Eduardo E. .

NEUROLOGY, 2009, 73 (16) :1323-1327

[4] Electrophysiological characteristics of reactive astrocytes in experimental cortical dysplasia [J].

Bordey, A ;

Lyons, SA ;

Hablitz, JJ ;

Sontheimer, H .

JOURNAL OF NEUROPHYSIOLOGY, 2001, 85 (04) :1719-1731

[5] Spatiotemporal neuronal correlates of seizure generation in focal epilepsy [J].

Bower, Mark R. ;

Stead, Matt ;

Meyer, Fredric B. ;

Marsh, W. Richard ;

Worrell, Gregory A. .

EPILEPSIA, 2012, 53 (05) :807-816

[6] Albumin is taken up by hippocampal NG2 cells and astrocytes and decreases gap junction coupling [J].

Braganza, Oliver ;

Bedner, Peter ;

Huettmann, Kerstin ;

von Staden, Elena ;

Friedman, Alon ;

Seifert, Gerald ;

Steinhaeuser, Christian .

EPILEPSIA, 2012, 53 (11) :1898-1906

[7] Hippocampal and entorhinal cortex high-frequency oscillations (100-500 Hz) in human epileptic brain and in kainic acid-treated rats with chronic seizures [J].

Bragin, A ;

Engel, J ;

Wilson, CL ;

Fried, I ;

Mathern, GW .

EPILEPSIA, 1999, 40 (02) :127-137

[8] Analysis of seizure onset on the basis of wideband EEG recordings [J].

Bragin, A ;

Wilson, CL ;

Fields, T ;

Fried, I ;

Engel, TJ .

EPILEPSIA, 2005, 46 :59-63

[9]

Bragin A, 1999, HIPPOCAMPUS, V9, P137

[10] Voltage depth profiles of high-frequency oscillations after kainic acid-induced status epilepticus [J].

Bragin, Anatol ;

Wilson, Charles L. ;

Engel, Jerome, Jr. .

EPILEPSIA, 2007, 48 :35-40

← 1 2 3 4 5 6 →