Overview of biological mechanisms of human carcinogens

被引：33

作者：

Birkett, Nicholas ^{[1
,2
]}

Al-Zoughool, Mustafa ^{[3
]}

Bird, Michael ^{[2
]}

Baan, Robert A. ^{[4
]}

Zielinski, Jan ^{[1
,2
]}

Krewski, Daniel ^{[1
,2
,5
]}

机构：

[1] Univ Ottawa, Sch Epidemiol & Publ Hlth, Ottawa, ON, Canada

[2] Univ Ottawa, Fac Med, McLaughlin Ctr Populat Hlth Risk Assessment, Ottawa, ON, Canada

[3] King Saud bin Abdulaziz Univ Hlth Sci, Dept Community & Environm Hlth, Riyadh, Saudi Arabia

[4] Int Agcy Res Canc, Lyon, France

[5] Risk Sci Int, Ottawa, ON, Canada

来源：

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS | 2019年 / 22卷 / 7-8期

基金：

加拿大自然科学与工程研究理事会;

关键词：

Human carcinogens; key characteristics; sources of evidence; carcinogenesis; mechanisms of action; EPSTEIN-BARR-VIRUS; HEPATITIS-B-VIRUS; SQUAMOUS-CELL CARCINOMA; MEDIATES EPIGENETIC REPRESSION; HELICOBACTER-PYLORI INFECTION; GLOBAL DNA HYPOMETHYLATION; NUCLEOTIDE EXCISION-REPAIR; BLOOD MONONUCLEAR-CELLS; EARLY ENDOTHELIAL-CELLS; HAMSTER EMBRYO CELLS;

D O I：

10.1080/10937404.2019.1643539

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

This review summarizes the carcinogenic mechanisms for 109 Group 1 human carcinogens identified as causes of human cancer through Volume 106 of the IARC Monographs. The International Agency for Research on Cancer (IARC) evaluates human, experimental and mechanistic evidence on agents suspected of inducing cancer in humans, using a well-established weight of evidence approach. The monographs provide detailed mechanistic information about all carcinogens. Carcinogens with closely similar mechanisms of action (e.g. agents emitting alpha particles) were combined into groups for the review. A narrative synopsis of the mechanistic profiles for the 86 carcinogens or carcinogen groups is presented, based primarily on information in the IARC monographs, supplemented with a non-systematic review. Most carcinogens included a genotoxic mechanism.

引用

页码：288 / 359

页数：72

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