Fibroblast growth factor 23 and its role in phosphate homeostasis

被引：51

作者：

Ramon, Isolde ^{[1
]}

Kleynen, Pierre ^{[1
]}

Body, Jean-Jacques ^{[1
]}

Karmali, Rafik ^{[1
]}

机构：

[1] Free Univ Brussels, Hop Univ Brugmann, Dept Internal Med Endocrinol, B-1020 Brussels, Belgium

来源：

EUROPEAN JOURNAL OF ENDOCRINOLOGY | 2010年 / 162卷 / 01期

关键词：

MATRIX EXTRACELLULAR PHOSPHOGLYCOPROTEIN; FAMILIAL TUMORAL CALCINOSIS; MEPE-ASARM-PEPTIDES; HYPOPHOSPHATEMIC RICKETS; PARATHYROID-HORMONE; 1-ALPHA; 25-DIHYDROXYVITAMIN D-3; PROTEOLYTIC CLEAVAGE; MINERAL METABOLISM; MISSENSE MUTATION; LEVELS PREDICT;

D O I：

10.1530/EJE-09-0597

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Phosphate homeostasis is complex and incompletely understood. The identification of different factors involved in the regulation of phosphate balance, also called phosphatonins, has largely changed our view on the regulation of phosphate homeostasis. The active role of bone has been demonstrated clearly. Currently, maintaining phosphate homeostasis is considered the result of a complex network of endocrine feedback loops between parathyroid gland, kidney, and bone. This review describes current knowledge on fibroblast growth factor 23, which is one of the best studied phosphatonins.

引用

页码：1 / 10

页数：10

共 81 条

[1] MEPE-ASARM peptides control extracellular matrix mineralization by binding to hydroxyapatite: An inhibition regulated by PHEX cleavage of ASARM [J].

Addison, William N. ;

Nakano, Yukiko ;

Loisel, Thomas ;

Crine, Phillippe ;

McKee, Marc D. .

JOURNAL OF BONE AND MINERAL RESEARCH, 2008, 23 (10) :1638-1649

[2] A novel mutation in fibroblast growth factor 23 gene as a cause of tumoral calcinosis [J].

Araya, K ;

Fukumoto, S ;

Backenroth, R ;

Takeuchi, Y ;

Nakayama, K ;

Ito, N ;

Yoshii, N ;

Yamazaki, Y ;

Yamashita, T ;

Silver, J ;

Igarashi, T ;

Fujita, T .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (10) :5523-5527

[3] Transgenic mice overexpressing human fibroblast growth factor 23 (R176Q) delineate a putative role for parathyroid hormone in renal phosphate wasting disorders [J].

Bai, XY ;

Miao, DS ;

Li, JR ;

Goltzman, D ;

Karaplis, AC .

ENDOCRINOLOGY, 2004, 145 (11) :5269-5279

[4] The autosomal dominant hypophosphatemic rickets R176Q mutation in fibroblast growth factor 23 resists proteolytic cleavage and enhances in vivo biological potency [J].

Bai, XY ;

Miao, DS ;

Goltzman, D ;

Karaplis, AC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (11) :9843-9849

[5] The parathyroid is a target organ for FGF23 in rats [J].

Ben-Dov, Iddo Z. ;

Galitzer, Hillel ;

Lavi-Moshayoff, Vardit ;

Goetz, Regina ;

Kuro-o, Makoto ;

Mohammadi, Moosa ;

Sirkis, Roy ;

Naveh-Many, Tally ;

Silver, Justin .

JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (12) :4003-4008

[6] An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia [J].

Benet-Pagès, A ;

Orlik, P ;

Strom, TM ;

Lorenz-Depiereux, B .

HUMAN MOLECULAR GENETICS, 2005, 14 (03) :385-390

[7] FGF23 is processed by proprotein convertases but not by PHEX [J].

Beret-Pagès, A ;

Lorenz-Depiereux, B ;

Zischka, H ;

White, KE ;

Econs, MJ ;

Strom, TM .

BONE, 2004, 35 (02) :455-462

[8] Phosphatonins and the regulation of phosphorus homeostasis [J].

Berndt, TJ ;

Schiavi, S ;

Kumar, R .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2005, 289 (06) :F1170-F1182

[9] Mineral metabolism, mortality, and morbidity in maintenance hemodialysis [J].

Block, GA ;

Klassen, PS ;

Lazarus, JM ;

Ofsthun, N ;

Lowrie, EG ;

Chertow, GM .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2004, 15 (08) :2208-2218

[10] Serum MEPE-ASARM-peptides are elevated in X-linked rickets (HYP): implications for phosphaturia and rickets [J].

Bresler, D ;

Bruder, J ;

Mohnike, K ;

Fraser, WD ;

Rowe, PSN .

JOURNAL OF ENDOCRINOLOGY, 2004, 183 (03) :R1-R9

← 1 2 3 4 5 6 7 8 9 →