Fibroblast growth factor 23 and its role in phosphate homeostasis

被引：48
|
作者：
Ramon, Isolde [1 ]
Kleynen, Pierre [1 ]
Body, Jean-Jacques [1 ]
Karmali, Rafik [1 ]
机构：
[1] Free Univ Brussels, Hop Univ Brugmann, Dept Internal Med Endocrinol, B-1020 Brussels, Belgium
来源：
EUROPEAN JOURNAL OF ENDOCRINOLOGY | 2010年 / 162卷 / 01期
关键词：
MATRIX EXTRACELLULAR PHOSPHOGLYCOPROTEIN; FAMILIAL TUMORAL CALCINOSIS; MEPE-ASARM-PEPTIDES; HYPOPHOSPHATEMIC RICKETS; PARATHYROID-HORMONE; 1-ALPHA; 25-DIHYDROXYVITAMIN D-3; PROTEOLYTIC CLEAVAGE; MINERAL METABOLISM; MISSENSE MUTATION; LEVELS PREDICT;
D O I：
10.1530/EJE-09-0597
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Phosphate homeostasis is complex and incompletely understood. The identification of different factors involved in the regulation of phosphate balance, also called phosphatonins, has largely changed our view on the regulation of phosphate homeostasis. The active role of bone has been demonstrated clearly. Currently, maintaining phosphate homeostasis is considered the result of a complex network of endocrine feedback loops between parathyroid gland, kidney, and bone. This review describes current knowledge on fibroblast growth factor 23, which is one of the best studied phosphatonins.
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页码：1 / 10
页数：10
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