Aging-related changes in metabolic indicators in female rats and their management with Tinospora cordifolia

被引:5
作者
Bhandari, Anmol [1 ]
Sharma, Ashwani Kumar [2 ]
Singh, Harpal [2 ]
Singh, Amritpal [1 ]
Kaur, Gurcharan [1 ]
机构
[1] Guru Nanak Dev Univ, Dept Biotechnol, Med Biotechnol Lab, Amritsar 143005, Punjab, India
[2] Guru Nanak Dev Univ, Dept Pharmaceut Sci, Amritsar 143005, Punjab, India
关键词
Aging; Dyslipidemia; High-fat diet; Metabolic indicators; Tinospora cordifolia; INSULIN-RESISTANCE; GENE-EXPRESSION; ADIPOSE-TISSUE; LIPID-METABOLISM; AMPK; LIVER; HYPERLIPIDEMIA; ANTIOXIDANT; OVARIECTOMY; MENOPAUSE;
D O I
10.1007/s10522-022-09962-1
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Conflicting reports of HRT necessitates exploration of therapeutic interventions with the least side effects to preserve metabolic homeodynamics in women later in life. The current study was designed to elucidate the cumulative effects of aging and/or high fat diet (HFD) on some metabolic indicators and their management by Tinospora cordifolia stem powder (TCP) using middle-aged acyclic and young adult cyclic female rats as the model system. Animals were fed on either normal chow or HFD supplemented with or without TCP. Blood and liver tissue were collected for biochemical, and histological studies as well as for expression of proteins regulating lipid metabolism. Animals fed with TCP supplemented normal chow feed showed bodyweight management over 12-weeks despite their high feed and calories intake compared to young and age-matched controls as well as HFD-fed animals. TCP dose used was not toxic and rather prevented age-associated liver dysfunctions and ameliorated dyslipidemia and oxidative stress, normalized blood glucose, insulin, leptin, and secretary pro-inflammatory cytokines. Further, bodyweight management effect of TCP was observed to target AMPK signalling pathway as the mediator of lipogenesis, sterol biosynthesis, lipolysis, and beta-oxidation of fatty acids. These findings suggest that TCP supplementation in diet may be a potential interventional strategy to ameliorate aging-associated hepatic and metabolic dysfunctions and to promote healthy aging. [GRAPHICS] .
引用
收藏
页码:363 / 380
页数:18
相关论文
共 57 条
[1]   Butanol Extract of Tinospora cordifolia Alleviates Acute Sleep Deprivation-Induced Impairments in Cognitive Functions and Neuromuscular Coordination in Middle-Aged Female Rats [J].
Bajaj, Payal ;
Singh, Harpal ;
Kalotra, Shikha ;
Kaur, Gurcharan .
NEUROMOLECULAR MEDICINE, 2022, 24 (02) :202-214
[2]  
Ban Y.H., 2018, Evid Based Complement Alternat Med, P2929107, DOI DOI 10.1155/2018/2929107
[3]   Ginkgo biloba extract (GbE) attenuates obesity and anxious/depressive-like behaviours induced by ovariectomy [J].
Banin, Renata Mancini ;
Forcelini Machado, Meira Maria ;
de Andrade, Iracema Senna ;
Testa Carvalho, Lorenza Oliveira ;
Hirata, Bruna Kelly Sousa ;
de Andrade, Heider Mendonca ;
Julio, Viviane da Silva ;
Figueiredo Borges Ribeiro, Jessica de Souza ;
Cerutti, Suzete Maria ;
Oyama, Lila Missae ;
Ribeiro, Eliane Beraldi ;
Telles, Monica Marques .
SCIENTIFIC REPORTS, 2021, 11 (01)
[4]   Metformin ameliorates body mass gain and early metabolic changes in ovariectomized rats [J].
Barthem, Clarissa Souza ;
Rossetti, Camila Ludke ;
Carvalho, Denise P. ;
da-Silva, Wagner Seixas .
ENDOCRINE CONNECTIONS, 2019, 8 (12) :1568-1578
[5]   Circulating levels of plasminogen activator inhibitor-1 are associated with metabolic syndrome rather than with menopause [J].
Basurto, Lourdes ;
Diaz, Alma ;
Rodriguez, Ana ;
Robledo, Ariadna ;
Vega, Sara ;
Garcia-Vega, Jessica ;
Martinez-Murillo, Carlos .
GYNECOLOGICAL ENDOCRINOLOGY, 2019, 35 (10) :909-912
[6]  
Bjorklund B.R., 2015, The journey of adulthood, V8th
[7]   Estrogen and voluntary exercise attenuate cardiometabolic syndrome and hepatic steatosis in ovariectomized rats fed a high-fat high-fructose diet [J].
Buniam, Jariya ;
Chukijrungroat, Natsasi ;
Khamphaya, Tanaporn ;
Weerachayaphorn, Jittima ;
Saengsirisuwan, Vitoon .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2019, 316 (05) :E908-E921
[8]   Estrogen regulation of adiposity and fuel partitioning - Evidence of genomic and non-genomic regulation of lipogenic and oxidative pathways [J].
D'Eon, TM ;
Souza, SC ;
Aronovitz, M ;
Obin, MS ;
Fried, SK ;
Greenberg, AS .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (43) :35983-35991
[9]  
Dhingra Dinesh, 2014, ISRN Pharmacol, V2014, P243575, DOI 10.1155/2014/243575
[10]  
Freeman EW, 2010, MENOPAUSE, V17, P718, DOI [10.1097/gme.0b013e3181cec85d, 10.1097/gme.0b013e3181db9f8b]