The same well-characterized T cell epitope SIINFEKL expressed in the context of a cytoplasmic or secreted protein in BCG induces different CD8+ T cell responses

被引：9

作者：

Hulseberg, Paul D. ^{[1
]}

Zozulya, Alla ^{[1
]}

Chu, Hamlet H. ^{[1
]}

Triccas, James A. ^{[2
]}

Fabry, Zsuzsanna ^{[1
]}

Sandor, Matyas ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Pathol & Lab Sci, Madison, WI 53706 USA

[2] Univ Sydney, Centenary Inst Canc Med & Cell Biol, Sydney, NSW 2006, Australia

来源：

IMMUNOLOGY LETTERS | 2010年 / 130卷 / 1-2期

关键词：

Mycobacterium; CD8(+) T cell responses; Antigen location; CLASS-I PRESENTATION; MYCOBACTERIUM-TUBERCULOSIS INFECTION; DENDRITIC CELLS; CROSS-PRESENTATION; ANTIGEN PRESENTATION; EXOGENOUS ANTIGENS; LISTERIA-MONOCYTOGENES; PARTICULATE ANTIGENS; PROCESSING PATHWAY; TAP-DEFICIENT;

D O I：

10.1016/j.imlet.2009.12.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mycobacterium bovis BCG is still the most widely used vaccine against tuberculosis and CD8(+) T cells play important roles in fighting infection. We investigated how well antigen is processed and presented to CD8(+) T cells using the same well-characterized CD8(+) T cell epitope SIINFEKL expressed in either a cytoplasmic (GFP-OVA) or secreted (85B-OVA) context from BCG. We report that secreted SIINFEKL from 85B-OVA BCG is presented better than cytoplasmic SIINFEKL expressed by GFP-OVA BCG. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：36 / 42

页数：7

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