Can combined T-cell- and antibody-based immunotherapy outsmart tumor cells?

被引：38

作者：

Abken, H ^{[1
]}

Hombach, A

Reinhold, U

Ferrone, S

机构：

[1] Univ Cologne, Dept Internal Med 1, Lab Tumor Genet, D-50924 Cologne, Germany

[2] Univ Homburg, Dept Dermatol, D-66421 Homburg, Germany

[3] New York Med Coll, Dept Microbiol & Immunol, Valhalla, NY 10595 USA

来源：

IMMUNOLOGY TODAY | 1998年 / 19卷 / 01期

关键词：

D O I：

10.1016/S0167-5699(97)01191-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Advantages of T-cell- and antibody-based immunotherapy can be combined by grafting cytotoxic T lymphocytes with chimeric receptors composed of antibody fragments (which recognize tumor-cell antigen) and a cellular activation motif. Here, Hinrich Abken and colleagues discuss the potential of this approach for immunotherapy of malignant diseases.

引用

页码：2 / 5

页数：6

共 25 条

[1]

BLANKVOORTHUIS CJAC, 1993, J IMMUNOL, V151, P2904

[2] SIGNALS THROUGH T-CELL RECEPTOR-ZETA CHAIN ALONE ARE INSUFFICIENT TO PRIME RESTING T-LYMPHOCYTES [J].

BROCKER, T ;

KARJALAINEN, K .

JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 181 (05) :1653-1659

[3] SPECIFIC ACTIVATION AND TARGETING OF CYTOTOXIC LYMPHOCYTES THROUGH CHIMERIC SINGLE CHAINS CONSISTING OF ANTIBODY-BINDING DOMAINS AND THE GAMMA-SUBUNIT OR ZETA-SUBUNIT OF THE IMMUNOGLOBULIN AND T-CELL RECEPTORS [J].

ESHHAR, Z ;

WAKS, T ;

GROSS, G ;

SCHINDLER, DG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (02) :720-724

[4] LOSS OF HLA CLASS-I ANTIGENS BY MELANOMA-CELLS - MOLECULAR MECHANISMS, FUNCTIONAL-SIGNIFICANCE AND CLINICAL RELEVANCE [J].

FERRONE, S ;

MARINCOLA, FM .

IMMUNOLOGY TODAY, 1995, 16 (10) :487-494

[5] HLA class I antigens in human tumors [J].

Garrido, F ;

Cabrera, T ;

LopezNevot, MA ;

RuizCabello, F .

ADVANCES IN CANCER RESEARCH, VOL 67, 1995, 67 :155-195

[6]

Hekele A, 1996, INT J CANCER, V68, P232, DOI 10.1002/(SICI)1097-0215(19961009)68:2<232::AID-IJC16>3.0.CO

[7]

2-C

[8]

HOMBACH A, 1997, GASTROENTEROLOGY, V113, P163

[9]

HWU P, 1995, CANCER RES, V55, P3369

[10] LYSIS OF OVARIAN-CANCER CELLS BY HUMAN-LYMPHOCYTES REDIRECTED WITH A CHIMERIC GENE COMPOSED OF AN ANTIBODY VARIABLE REGION AND THE FC-RECEPTOR GAMMA-CHAIN [J].

HWU, P ;

SHAFER, GE ;

TREISMAN, J ;

SCHINDLER, DG ;

GROSS, G ;

COWHERD, R ;

ROSENBERG, SA ;

ESHHAR, Z .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (01) :361-366

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