RETRACTED: Evaluation of Liquid Biopsy in Patients with HER2-Positive Breast Cancer (Retracted Article)

被引：5

作者：

Huai, Jianguo ^{[1
]}

Cao, Ming ^{[1
]}

Jiang, Yan ^{[1
]}

Yang, Xiaomiao ^{[1
]}

Zhu, Yanyan ^{[1
]}

Si, Youyi ^{[1
]}

Xu, Man ^{[1
]}

Shen, Chenxiang ^{[1
]}

Han, Tao ^{[2
]}

Lian, Xiaochun ^{[2
]}

机构：

[1] Wuhu No 1 Peoples Hosp, Dept Pathol, Wuhu, Peoples R China

[2] Wuhu No 1 Peoples Hosp, Dept Breast Surg, Wuhu, Peoples R China

来源：

BIOMED RESEARCH INTERNATIONAL | 2021年 / 2021卷

关键词：

CIRCULATING TUMOR-CELLS;

D O I：

10.1155/2021/6388492

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Breast cancer is one of the common malignant tumors, and liquid biopsy has become a hot spot for clinical testing. To clarify the detection effect of liquid biopsy in breast cancer, we collected peripheral blood of HER2-positive (human epidermal growth factor receptor 2-positive) patients. Circulating tumor cells (CTCs) were isolated and analyzed. HER2 expression on CTCs was detected. The results showed that in the 198 HER2-positive samples, the CTC detection rate was 79.8% (158/198), and the mean number of CTCs was 21, ranging from 1 to 63/7.5 mL peripheral blood. Only 41.1% (65/158) of patients had histology and CTC HER2 status consistent with the remaining 58.9% (93/158) of patients, although their histological HER2 was positive, and CTC HER2 was negative. Our study confirmed the value of CTC HER2 real-time status testing in HER2-positive breast cancer patients. The inconsistency in HER2 status between CTCs and histology may be related to the time interval between CTCs and histological HER2 detection, suggesting that real-time HER2 detection is necessary for histological HER2-positive patients.

引用

页数：5

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