Molecular and epidemiologic characteristics of linezolid-resistant coagulase-negative staphylococci at a tertiary care hospital

被引：29
|
作者：
Kosowska-Shick, Klaudia [1 ]
Julian, Kathleen G. [2 ]
McGhee, Pamela L. [1 ]
Appelbaum, Peter C. [1 ]
Whitener, Cynthia J. [2 ]
机构：
[1] Penn State Hershey Med Ctr, Dept Pathol, Hershey, PA 17033 USA
[2] Penn State Hershey Med Ctr, Dept Med, Hershey, PA 17033 USA
来源：
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2010年 / 68卷 / 01期
关键词：
Staphylococcus epidermidis; Coagulase-negative staphylococci; Linezolid-resistant; Bacteremia; 23S RIBOSOMAL-RNA; AUREUS; EPIDERMIDIS; EMERGENCE; THERAPY; STRAIN;
D O I：
10.1016/j.diagmicrobio.2010.05.007
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
We investigated emergence of linezolid resistance among coagulase-negative staphylococci at our tertiary care center in 2007. All 17 cases were healthcare associated, and prior administration of linezolid was documented <= 2 months before first isolation of linezolid-resistant coagulase-negative staphylococci for all but 1 patient. Pulse-field gel electrophoresis analysis of the 14 available strains demonstrated 1 predominant clonal type, suggesting nosocomial spread. In addition to mutations in 23S rRNA and L4 previously described, we observed novel alterations in the 23S rRNA gene (G(2215)A) and in the L3 protein (substitutions L101V, H(146)Q/R, F147I, V154L, M156T). The increase in linezolid-resistant coagulase-negative staphylococci correlated with nosocomial transmission of selected mutated strains in patients who had received linezolid. (c) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码：34 / 39
页数：6
相关论文
共 50 条
  • [1] Linezolid-Resistant Coagulase-Negative Staphylococci in a Tertiary Hospital: Molecular Epidemiology, Clinical Characteristics, and Outcomes
    Rachina, Svetlana
    Gostev, Vladimir
    Pleshkov, Vyacheslav
    Karpova, Olga
    Topolyanskaya, Svetlana
    Melkonyan, Georgy
    Gladkikh, Marina
    Zainalabidova, Khadizhat
    Chulkova, Polina
    Sidorenko, Sergey
    INFECTION AND CHEMOTHERAPY, 2025, 57 (01): : 161 - 167
  • [2] Emergence of linezolid-resistant coagulase-negative staphylococci in an intensive care unit
    Balandin, Barbara
    Lobo, Beatriz
    Orden, Beatriz
    Roman, Federico
    Garcia, Elena
    Martinez, Rocio
    Valdivia, Miguel
    Ortega, Alfonso
    Fernandez, Inmaculada
    Galdos, Pedro
    INFECTIOUS DISEASES, 2016, 48 (05) : 343 - 349
  • [3] Emergence of linezolid-resistant coagulase-negative staphylococci in an Intensive Care Unit
    Zarkotou, O.
    Chrysos, G.
    Magira, E.
    Altouvas, G.
    Prekates, A.
    Digalaki, K.
    Tsakris, A.
    INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2010, 14 : E347 - E347
  • [4] Epidemiological profile of linezolid-resistant coagulase-negative staphylococci
    Potoski, Brian A.
    Adams, Jennifer
    Clarke, Lloyd
    Shutt, Kathleen
    Linden, Peter K.
    Baxter, Carla
    Pasculle, A. William
    Capitano, Blair
    Peleg, Anton Y.
    Szabo, Dora
    Paterson, David L.
    CLINICAL INFECTIOUS DISEASES, 2006, 43 (02) : 165 - 171
  • [5] Global Expansion of Linezolid-Resistant Coagulase-Negative Staphylococci
    Gostev, Vladimir
    Leyn, Semen
    Kruglov, Alexander
    Likholetova, Daria
    Kalinogorskaya, Olga
    Baykina, Marina
    Dmitrieva, Natalia
    Grigorievskaya, Zlata
    Priputnevich, Tatiana
    Lyubasovskaya, Lyudmila
    Gordeev, Alexey
    Sidorenko, Sergey
    FRONTIERS IN MICROBIOLOGY, 2021, 12
  • [6] Antimicrobial susceptibility patterns of Linezolid-resistant coagulase-negative staphylococci in Pakistan
    Sattar, Arooj
    Mahmood, Namra
    Riaz, Zahra
    Yousaf, Iram
    Hafeez, Rubeena
    Jamil, Sakina
    KHYBER MEDICAL UNIVERSITY JOURNAL-KMUJ, 2024, 16 (03): : 182 - 186
  • [7] Characterization of linezolid- and methicillin-resistant coagulase-negative staphylococci in a tertiary hospital in China
    Liu, Cailin
    Yu, Jing
    Chen, Chunguang
    Li, Xiaogai
    Ye, Yafei
    Dong, Yani
    Ying, Xinxin
    Li, Haijun
    Wang, Wanhai
    BMC INFECTIOUS DISEASES, 2024, 24 (01)
  • [8] Clinical and epidemiologic significance of coagulase-negative staphylococci bacteremia in a tertiary care university Israeli hospital
    Finkelstein, R
    Fusman, R
    Oren, I
    Kassis, I
    Hashman, N
    AMERICAN JOURNAL OF INFECTION CONTROL, 2002, 30 (01) : 21 - 25
  • [9] Linezolid-resistant clinical isolates of meticillin-resistant coagulase-negative staphylococci and Enterococcus faecium from China
    Cai, Jia Chang
    Hu, Yan Yan
    Zhang, Rang
    Zhou, Hong Wei
    Chen, Gong-Xiang
    JOURNAL OF MEDICAL MICROBIOLOGY, 2012, 61 (11) : 1568 - 1573
  • [10] RESISTANT COAGULASE-NEGATIVE STAPHYLOCOCCI IN HOSPITAL PATIENTS
    POWELL, M
    SANDERSON, PJ
    JOURNAL OF HOSPITAL INFECTION, 1987, 9 (01) : 48 - 53
12345