Amyloid pathology and protein kinase C (PKQ): Possible therapeutics effects of PKC activators

被引：18
作者：
Olariu, A [1 ]
Yamada, K
Nabeshima, T
机构：
[1] NIMH, Unit Neuroplastic, NIH, Bethesda, MD 20892 USA
[2] Kanazawa Univ, Grad Sch Nat Sci & Technol, Div Life Sci, Neuropharmacol Lab, Kanazawa, Ishikawa 9201192, Japan
[3] Nagoya Univ, Grad Sch Med, Dept Neuropsychopharmacol & Hosp Pharm, Nagoya, Aichi 4668560, Japan
来源：
JOURNAL OF PHARMACOLOGICAL SCIENCES | 2005年 / 97卷 / 01期
关键词：
amyloid protein; Alzheimer's disease; signal transduction; protein kinase C; cell death;
D O I：
10.1254/jphs.CPJ04004X
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Amyloid beta-protein (Abeta) is one of the most studied peptides in human neurodegenerative disorders. Although much has been learned about the biochemistry of this peptide, fundamental questions such as when and how the Abeta becomes pathologic remain unanswered. In this article we review the recent findings on the biology and pathology of Abeta and the role protein kinase C (PKC) plays in these processes. The potential neuroprotective role of PKC and the possible therapeutic effects of PKC activators in Alzheimer's disease (AD) will be discussed. Briefly, comments will be also addressed on the role of PKC in cell death and neurogenesis in AD.
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页码：1 / 5
页数：5
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