Janus Kinase Inhibitors in Dermatology: Part 1 - General Considerations and Applications in Vitiligo and Alopecia Areata

被引：15
作者：
Garcia-Melendo, C. [1 ]
Cubiro, X. [1 ]
Puig, L. [1 ]
机构：
[1] Univ Autonoma Barcelona, Serv Dermatol, Hosp Santa Creu & St Pau, Barcelona, Spain
来源：
ACTAS DERMO-SIFILIOGRAFICAS | 2021年 / 112卷 / 06期
关键词：
JAK/STAT pathway; Janus kinase inhibitors; Vitiligo; Alopecia areata; RHEUMATOID-ARTHRITIS; ATOPIC-DERMATITIS; ORAL TOFACITINIB; TOPICAL RUXOLITINIB; INADEQUATE RESPONSE; UNIVERSALIS; BARICITINIB; PLACEBO; PATIENT; SAFETY;
D O I：
10.1016/j.ad.2020.12.003
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Dermatologists' interest in the Janus-associated kinase/signal transducers and activators of transcription (JAK/STAT) pathway has been growing as evidence builds to support its key role in the pathogenesis of inflammatory skin diseases. Because certain proinflammatory cytokines use the JAK/STAT pathway for signal transduction, it has become a promising therapeutic target in diseases where selective modulation of the immune system can be useful. We aim to review current knowledge of the JAK/STAT signaling pathway and its role in immune-mediated skin diseases. In the first part of the review we cover the efficacy and safety of oral and topical JAK inhibitors in the treatment of vitiligo and alopecia areata. (C) 2020 AEDV. Published by Elsevier Espana, S.L.U.
引用
收藏
页码：503 / 515
页数：13
相关论文
共 97 条
  • [1] Janus Kinase Inhibitors for the Treatment of Severe Alopecia Areata: An Open-Label Comparative Study
    Almutairi, Nawaf
    Nour, Tarek M.
    Hussain, Nasser Haji
    [J]. DERMATOLOGY, 2019, 235 (02) : 130 - 136
  • [2] [Anonymous], STUDY INCB018424 PHO
  • [3] [Anonymous], TOPICAL RUXOLITINIB
  • [4] [Anonymous], 2004, **DROPPED REF**, DOI DOI 10.1111/J.1524-4725.2004.30058.X
  • [5] [Anonymous], Effectiveness and safety of COVID-19 vaccine in pregnant women: A systematic review with meta -analysis
  • [6] [Anonymous], A study to evaluate the efficacy and safety of pemigatinib versus chemotherapy in unresectable or metastatic cholangiocarcinoma (FIGHT -302)
  • [7] [Anonymous], LEO 124249 OINTMENT
  • [8] [Anonymous], 2019, FDA APPROVES BOXED W
  • [9] [Anonymous], **DROPPED REF**
  • [10] Topical Janus kinase inhibitors for the treatment of pediatric alopecia areata
    Bayart, Cheryl B.
    DeNiro, Katherine L.
    Brichta, Lars
    Craiglow, Brittany G.
    Sidbury, Robert
    [J]. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2017, 77 (01) : 167 - 170
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