Recurrent pituitary ependymoma: a complex clinical problem

被引:8
作者
Belcher, Rosie [2 ]
Chahal, Harvinder S. [2 ]
Evanson, Jane [3 ]
Afshar, Farhad [4 ]
Marino, Silvia [5 ]
Grossman, Ashley B. [1 ]
机构
[1] St Bartholomews Hosp, Dept Endocrinol, London EC1A 7BE, England
[2] Barts & London Queen Marys Sch Med & Dent, Dept Endocrinol, London, England
[3] Barts & London Queen Marys Sch Med & Dent, Dept Radiol, London, England
[4] Barts & London Queen Marys Sch Med & Dent, Dept Neurosurg, London, England
[5] Barts & London Queen Marys Sch Med & Dent, Dept Histopathol, London, England
关键词
Ependymoma; Pituitary tumor; Radiotherapy; POSTERIOR-FOSSA EPENDYMOMAS; INTRACRANIAL EPENDYMOMAS; PROGNOSTIC-FACTORS; SUPRATENTORIAL EPENDYMOMAS; RADIATION-THERAPY; IMPROVED SURVIVAL; ADULT PATIENTS; FOLLOW-UP; RADIOTHERAPY; PATTERNS;
D O I
10.1007/s11102-008-0139-x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Ependymomas rarely arise from the region of the pituitary fossa, with only four cases previously reported in the literature. We present a complex case of a recurrent ependymoma of the parasellar region which has been difficult to clinically manage due to its tendency to recurrence. Our patient has had four operations over the last 28 years, with external beam radiotherapy, but still has residual tumor and is currently panhypopituitary and with significant visual loss. We believe there is considerable uncertainty as to the optimal management of any future progression, which seems likely, and are currently considering the use of radiosurgery with careful sparing of the optic chiasm, or possibly the chemotherapeutic agent temozolomide. Our case emphasises the recurrent nature of this rare but difficult tumor.
引用
收藏
页码:176 / 182
页数:7
相关论文
共 50 条
[1]   EPENDYMOMAS - A CLINICAL SURVEY [J].
BARONE, BM ;
ELVIDGE, AR .
JOURNAL OF NEUROSURGERY, 1970, 33 (04) :428-&
[2]   A multicenter retrospective study of chemotherapy for recurrent intracranial ependymal tumors in adults by the Gruppo Italiano Cooperativo di Neuro-Oncologia [J].
Brandes, AA ;
Cavallo, G ;
Reni, M ;
Tosoni, A ;
Nicolardi, L ;
Scopece, L ;
Franceschi, E ;
Sotti, G ;
Talacchi, A ;
Turazzi, S ;
Ermani, M .
CANCER, 2005, 104 (01) :143-148
[3]   SUPRATENTORIAL EPENDYMOMAS - NEUROIMAGING AND CLINICOPATHOLOGICAL CORRELATION [J].
CENTENO, RS ;
LEE, AA ;
WINTER, J ;
BARBA, D .
JOURNAL OF NEUROSURGERY, 1986, 64 (02) :209-215
[4]   Phase II study of neoadjuvant 1, 3-bis (2-chloroethyl)-1-nitrosourea and temozolomide for newly diagnosed anaplastic glioma - A North American Brain Tumor Consortium Trial [J].
Chang, SM ;
Prados, MD ;
Yung, WKA ;
Fine, H ;
Junck, L ;
Greenberg, H ;
Robins, HI ;
Mehta, M ;
Fink, KL ;
Jaeckle, KA ;
Kuhn, J ;
Hess, K ;
Schold, C .
CANCER, 2004, 100 (08) :1712-1716
[5]   Intracranial and spinal ependymomas: Review of MR images in 61 patients [J].
Choi, JY ;
Chang, KH ;
Yu, IK ;
Kim, KH ;
Kwon, BJ ;
Han, MH ;
Kim, IO .
KOREAN JOURNAL OF RADIOLOGY, 2002, 3 (04) :219-228
[6]   SUPRATENTORIAL EPENDYMOMAS AND SUBEPENDYMOMAS - CT AND MR APPEARANCE [J].
FURIE, DM ;
PROVENZALE, JM .
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 1995, 19 (04) :518-526
[7]  
GOLDWEIN JW, 1990, CANCER-AM CANCER SOC, V66, P557, DOI 10.1002/1097-0142(19900801)66:3<557::AID-CNCR2820660325>3.0.CO
[8]  
2-8
[9]   Chemotherapy for advanced CNS ependymoma [J].
Gornet, MK ;
Buckner, JC ;
Marks, RS ;
Scheithauer, BW ;
Erickson, BJ .
JOURNAL OF NEURO-ONCOLOGY, 1999, 45 (01) :61-67
[10]   Intracranial ependymomas in adult patients: analyses of prognostic factors [J].
Guyotat, J ;
Signorelli, F ;
Desme, S ;
Frappaz, D ;
Madarassy, G ;
Montange, MF ;
Jouvet, A ;
Bret, P .
JOURNAL OF NEURO-ONCOLOGY, 2002, 60 (03) :255-268