Effects of MPSS and a potent iNOS inhibitor on traumatic spinal cord injury

被引：30

作者：

Yu, YM ^{[1
]}

Matsuyama, Y

Nakashima, S

Yanase, M

Kiuchi, K

Ishiguro, N

机构：

[1] Nagoya Univ, Sch Med, Dept Orthoped Surg, Nagoya, Aichi 4668550, Japan

[2] Nagoya Kyoritsu Hosp, Nagoya, Aichi 4540933, Japan

[3] Gifu Univ, Fac Engn, Dept Biomol Sci, Gifu 5011193, Japan

来源：

NEUROREPORT | 2004年 / 15卷 / 13期

关键词：

apoptosis; iNOS; MPSS; ONO-1714; spinal cord injury; urinary bladder disability;

D O I：

10.1097/00001756-200409150-00021

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

ONO-1714, a selective inhibitor of inducible nitric oxide synthetase (iNOS) attenuated the increase of apoptosis and improved the functional outcome of urinary bladder after traumatic spinal cord injury. These findings suggest that iNOS plays a role in the process of SCI. Early treatment with 30 mg/kg methylprednisolone sodium succinate (MPSS) could also inhibit the expression of iNOS gene, apoptosis and the loss of urinary bladder function. We confirmed that early MPSS treatment may prevent injury associated with apoptosis and urinary bladder disability by reducing iNOS mRNA. However, delayed single MPSS treatment 8 h after spinal cord injury was not effective. Early repeated MPSS treatment might allow greater recovery from acute spinal cord injury.

引用

页码：2103 / 2107

页数：5

共 23 条

[1]

Allen A., 1911, J AM MED ASS, V57, P878, DOI 10.1001/jama.1911.04260090100008

[2] IMMUNOSUPPRESSION BY GLUCOCORTICOIDS - INHIBITION OF NF-KAPPA-B ACTIVITY THROUGH INDUCTION OF I-KAPPA-B SYNTHESIS [J].

AUPHAN, N ;

DIDONATO, JA ;

ROSETTE, C ;

HELMBERG, A ;

KARIN, M .

SCIENCE, 1995, 270 (5234) :286-290

[3] METHYLPREDNISOLONE OR NALOXONE TREATMENT AFTER ACUTE SPINAL-CORD INJURY - 1-YEAR FOLLOW-UP DATA - RESULTS OF THE 2ND NATIONAL ACUTE SPINAL-CORD INJURY STUDY [J].

BRACKEN, MB ;

SHEPARD, MJ ;

COLLINS, WF ;

HOLFORD, TR ;

BASKIN, DS ;

EISENBERG, HM ;

FLAMM, E ;

LEOSUMMERS, L ;

MAROON, JC ;

MARSHALL, LF ;

PEROT, PL ;

PIEPMEIER, J ;

SONNTAG, VKH ;

WAGNER, FC ;

WILBERGER, JL ;

WINN, HR ;

YOUNG, W .

JOURNAL OF NEUROSURGERY, 1992, 76 (01) :23-31

[4] CORRELATION OF METHYLPREDNISOLONE LEVELS IN CAT SPINAL-CORD WITH ITS EFFECTS ON (NA+ + K+)-ATPASE, LIPID-PEROXIDATION, AND ALPHA-MOTOR NEURON FUNCTION [J].

BRAUGHLER, JM ;

HALL, ED .

JOURNAL OF NEUROSURGERY, 1982, 56 (06) :838-844

[5]

Brunetti L, 1994, Clin Ter, V144, P147

[6] THE EFFECTS OF METHYLPREDNISOLONE AND THE GANGLIOSIDE GM1 ON ACUTE SPINAL-CORD INJURY IN RATS [J].

CONSTANTINI, S ;

YOUNG, W .

JOURNAL OF NEUROSURGERY, 1994, 80 (01) :97-111

[7] ORGANIZATION OF THE SACRAL PARASYMPATHETIC REFLEX PATHWAYS TO THE URINARY-BLADDER AND LARGE-INTESTINE [J].

DEGROAT, WC ;

NADELHAFT, I ;

MILNE, RJ ;

BOOTH, AM ;

MORGAN, C ;

THOR, K .

JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM, 1981, 3 (2-4) :135-160

[8]

DEGROAT WC, 1993, AUTONOMIC NERVOUS SY, V3, P227

[9]

DUCKER TB, 1978, SURG NEUROL, V10, P60

[10] Acute spinal cord injury, part I: Pathophysiologic mechanisms [J].

Dumont, RJ ;

Okonkwo, DO ;

Verma, RS ;

Hurlbert, RJ ;

Boulos, PT ;

Ellegala, DB ;

Dumont, AS .

CLINICAL NEUROPHARMACOLOGY, 2001, 24 (05) :254-264

← 1 2 3 →