Primary brain calcification in patients undergoing treatment with the biphosphanate alendronate

被引:32
作者
Oliveira, J. R. M. [1 ]
Oliveira, M. F. [2 ]
机构
[1] Univ Fed Pernambuco, Dept Neuropsychiat, Recife, PE, Brazil
[2] Hosp Serv Publ Estadual Sao Paulo, Dept Neurosurg, Sao Paulo, SP, Brazil
来源
SCIENTIFIC REPORTS | 2016年 / 6卷
关键词
MUTATIONS; SLC20A2; GENE;
D O I
10.1038/srep22961
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Brain calcification might be associated with various metabolic, infectious or vascular conditions. Clinically, brain calcification can include symptons such as migraine, parkinsonism, psychosis or dementia. The term Primary Brain Calcification was recently used for those patients without an obvious cause (formerly idiopathic) while Primary Familial Brain Calcifications was left for the cases with autosomal dominant inheritance. Recent studies found mutations in four genes (SLC20A2, PDGFRB, PDGFB and XPR1). However, these gene represent only 60% of all familial cases suggesting other genes remain to be elucidated. Studies evaluating treatments for such a devastating disease are scattered, usually appearing as single case reports. In the present study, we describe a case series of 7 patients treated with Alendronate, a widely prescribed biphosphanate. We observed good tolerance and evidence of improvements and stability by some patients. No side effects were reported and no specific symptoms related to medication. Younger patients and one individual continuing a prescription (prior to study commencement) appeared to respond more positively with some referred improvements in symptoms. Biphosphanates may represent an excellent prospect for the treatment of brain calcifications due to their being well tolerated and easily available. Conversely, prospective and controlled studies should promptly address weaknesses found in the present analysis.
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页数:5
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