New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals

被引：497

作者：

Hinuma, S

Shintani, Y

Fukusumi, S

Iijima, N

Matsumoto, Y

Hosoya, M

Fujii, R

Watanabe, T

Kikuchi, K

Terao, Y

Yano, T

Yamamoto, T

Kawamata, Y

Habata, Y

Asada, M

Kitada, C

Kurokawa, T

Onda, H

Nishimura, O

Tanaka, M

Ibata, Y

Fujino, M

机构：

[1] Takeda Chem Ind Ltd, Pharmaceut Discovery Res Div, Tsukuba, Ibaraki 3004293, Japan

[2] Kyoto Prefectural Univ Med, Dept Anat & Neurobiol, Kamikyo Ku, Kyoto 6020841, Japan

[3] Kyoto Prefectural Univ Med, Dept Neurol, Kamikyo Ku, Kyoto 6020841, Japan

来源：

NATURE CELL BIOLOGY | 2000年 / 2卷 / 10期

关键词：

D O I：

10.1038/35036326

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Only a few RFamide peptides have been identified in mammals, although they have been abundantly found in invertebrates. Here we report the identification of a human gene that encodes at least three RFamide-related peptides, hRFRP-1-3. Cells transfected with a seven-transmembrane-domain receptor, 0T7T022, specifically respond to synthetic hRFRP-1 and hRFRP-3 but not to hRFRP-2. RFRP and 0T7T022 mRNAs are expressed in particular regions of the rat hypothalamus, and intracerebroventricular administration of hRFRP-1 increases prolactin secretion in rats. Our results indicate that a variety of RFamide-related peptides may exist and function in mammals.

引用

页码：703 / 708

页数：6

共 33 条

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