Impact of a single dose of the 7-valent pneumococcal conjugate vaccine on colonization

被引：9
作者：
Frazao, Nelson [1 ,2 ]
Sa-Leao, Raquel [2 ,3 ]
de Lencastre, Herminia [1 ,2 ]
机构：
[1] Rockefeller Univ, Microbiol Lab, New York, NY 10065 USA
[2] Univ Nova Lisboa, Inst Tecnol Quim & Biol, Mol Genet Lab, P-2780156 Oeiras, Portugal
[3] Univ Lisbon, CMAF, P-1699 Lisbon, Portugal
来源：
VACCINE | 2010年 / 28卷 / 19期
关键词：
7-Valent pneumococcal conjugate vaccine; Single and multiple colonization; Streptococcus pneumoniae; RESISTANT STREPTOCOCCUS-PNEUMONIAE; DAY-CARE-CENTERS; NASOPHARYNGEAL COLONIZATION; GENETIC DIVERSITY; OTITIS-MEDIA; RISK-FACTORS; CHILDREN; CARRIAGE; SEROTYPES; DISEASE;
D O I：
10.1016/j.vaccine.2010.02.070
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The impact of the 7-valent pneumococcal conjugate vaccine (PCV7) on the pneumococcal flora has been mostly studied without evaluating multiple colonization and the mechanism(s) leading to serotype replacement. These issues are addressed here, while assessing the effect of a single PCV7 dose A group of children received one PCV7 dose just after nasopharyngeal sampling, with the control receiving no vaccine and both groups being sampled again a month later Up to 10 pneumococcal isolates were recovered per colonized child-1224 isolates were serotyped and representative ones characterized by pulsed-field gel electrophoresis In vaccinated children. serotype replacement between vaccine (VT) and non-vaccine (NVT) types occurred in single and multiple carriers, and VTs were less prone to be de novo acquired. NVT unmasking was only detected in the vaccinated group One month after vaccination with a single dose. PCV7 prevents VT de novo acquisition and promotes NVT unmasking. (C) 2010 Elsevier Ltd All rights reserved
引用
收藏
页码：3445 / 3452
页数：8
相关论文
共 44 条
[1]  
[Anonymous], 2000, MMWR Recomm Rep, V49, P1
[2]  
[Anonymous], 1999, Wkly Epidemiol Rec, V74, P177
[3]  
AURANEN K, 2009, AM J EPIDEMIOLOG DEC
[4]   Could a single dose of pneurnococcal conjugate vaccine in children be effective? Modeling the optimal age of vaccination [J].
Barzilay, EJ ;
O'Brien, KL ;
Kwok, YS ;
Hoekstra, RM ;
Zell, ER ;
Reid, R ;
Santosham, M ;
Whitney, CG ;
Feikin, DR .
VACCINE, 2006, 24 (07) :904-913
[5]   Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children [J].
Black, S ;
Shinefield, H ;
Fireman, B ;
Lewis, E ;
Ray, P ;
Hansen, JR ;
Elvin, L ;
Ensor, KM ;
Hackell, J ;
Siber, G ;
Malinoski, F ;
Madore, D ;
Chang, I ;
Kohberger, R ;
Watson, W ;
Austrian, R ;
Edwards, K .
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2000, 19 (03) :187-195
[6]   Streptococcus pneumoniae colonisation:: the key to pneumococcal disease [J].
Bogaert, D ;
de Groot, R ;
Hermans, PWM .
LANCET INFECTIOUS DISEASES, 2004, 4 (03) :144-154
[7]   Colonisation by Streptococcus pneumoniae and Staphylococcus aureus in healthy children [J].
Bogaert, D ;
van Belkum, A ;
Sluijter, M ;
Luijendijk, A ;
de Groot, R ;
Rümke, HC ;
Verbrugh, HA ;
Hermans, PWM .
LANCET, 2004, 363 (9424) :1871-1872
[8]   Vaccine escape recombinants emerge after pneumococcal vaccination in the united states [J].
Brueggemann, Angela B. ;
Pai, Rekha ;
Crook, Derrick W. ;
Beall, Bernard .
PLOS PATHOGENS, 2007, 3 (11) :1628-1636
[9]   A CLUSTER OF INVASIVE PNEUMOCOCCAL DISEASE IN YOUNG-CHILDREN IN CHILD-CARE [J].
CHERIAN, T ;
STEINHOFF, MC ;
HARRISON, LH ;
ROHN, D ;
MCDOUGAL, LK ;
DICK, J .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1994, 271 (09) :695-697
[10]   Impact of pneumococcal conjugate vaccine and of reduction of antibiotic use on nasopharyngeal carriage of nonsusceptible pneumococci in children with acute otitis media [J].
Cohen, Robert ;
Levy, Corinne ;
de La Rocque, France ;
Gelbert, Nathalie ;
Wollner, Alain ;
Fritzell, Bernard ;
Bonnet, Eric ;
Tetelboum, Robert ;
Varon, Emmanuelle .
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2006, 25 (11) :1001-1007
12345