Two new cytotoxic tetracyclic tetraterpenoids from the soft coral Sarcophyton tortuosum

被引：53

作者：

Zeng, LM ^{[1
]}

Lan, WJ

Su, JY

Zhang, GW

Feng, XL

Liang, YJ

Yang, XP

机构：

[1] Sun Yat Sen Univ, Sch Chem & Chem Engn, Guangzhou 510275, Peoples R China

[2] Jinan Univ, Inst Traditit Chinese Med & Nat Prod, Guangzhou 510275, Peoples R China

[3] Sun Yat Sen Univ, Instrumentat Anal & Res Ctr, Guangzhou 510275, Peoples R China

[4] Sun Yat Sen Univ, Ctr Canc, Guangzhou 510060, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2004年 / 67卷 / 11期

关键词：

D O I：

10.1021/np0400151

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new cytotoxic tetracyclic tetraterpenoids, methyl tortuoate A (1) and methyl tortuoate B (2), along with the known methyl sartortuoate (3) were isolated from the soft coral Sarcophyton tortuosum. The structures of 1 and 2 were established by spectroscopic methods, mainly on the basis of 2D NMR techniques, and were confirmed by single-crystal X-ray diffraction analysis. The cytotoxic activities of these compounds were carried out in vitro on human nasophyringeal carcinoma (CNE-2) and murine lymphocytic leukemia (P-388) tumor cell lines.

引用

页码：1915 / 1918

页数：4

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