Preparation and Characterization of Zwitterionic Poly(β-cyclodextrin-co-guanidinocitrate) Hydrogels for Ciprofloxacin Controlled Release

被引：28

作者：

Heydari, Abolfazl ^{[1
]}

Pardakhti, Abbas ^{[2
]}

Sheibani, Hassan ^{[1
]}

机构：

[1] Shahid Bahonar Univ Kerman, Dept Chem, Kerman 76169, Iran

[2] Kerman Univ Med Sci, Neuropharmacol Inst, Pharmaceut Res Ctr, Kerman 76169, Iran

来源：

MACROMOLECULAR MATERIALS AND ENGINEERING | 2017年 / 302卷 / 06期

关键词：

beta-cyclodextrin polymers; ciprofloxacin; controlled release; hydrogels; polyzwitterionic; BETA-CYCLODEXTRIN POLYMERS; HEAVY-METALS; CATIONIC POLYMERS; INCLUSION COMPLEX; DELIVERY; ADSORPTION; REMOVAL; MICROSPHERES; INHIBITION; SORPTION;

D O I：

10.1002/mame.201600501

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

A facile, safe, and environmentally friendly approach to the preparation of poly(beta-cyclodextrin-co-guanidinocitrate) (ZW beta CDP) via polymerization of beta-cyclodextrin (beta-CD) in the presence of guanidinocitrate as a novel cross-linker is reported. Novel zwitterionic guanidinocitrate cross-linker is synthesized by in situ reaction of melted guanidine and citric acid during polymerization. The structure of achieved hydrogels is characterized by attenuated total reflection-Fourier-transform infrared (ATR-FTIR), X-ray photoelectron spectroscopy, thermogravimetric analysis, differential thermogravimetric, differential scanning calorimetry (DSC), differential of DSC, and X-ray diffraction analyses and also by Kjeldahl and colorimetric methods for elemental analyses. The swelling ratio of the anionic beta-CD polymer (AN beta CDP) and ZW beta CDPs is determined in water and simulated physiological media. Subsequently, the hydrogels/ciprofloxacin (CFX, as a model antibiotic drug) complexes are prepared to improve the thermal stability of CFX and define potential pharmaceutical applications of hydrogels. Solid-state characterization of hydrogels/CFX complexes is investigated by ATR-FTIR and DSC. The in vitro release behavior of CFX from hydrogels is investigated at simulated physiological media, which exhibit initial burst and then slow drug release. The CFX release from ZW beta CDP is slower than AN beta CDP.

引用

页数：13

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