Tumor heterogeneity-based resistance guides personalized cancer medicine

被引：5

作者：

Lianos, Georgios D. ^{[1
,2
]}

Mangano, Alberto ^{[3
]}

Rausei, Stefano ^{[3
]}

Katsios, Christos ^{[2
]}

Roukos, Dimitrios H. ^{[1
,2
,4
]}

机构：

[1] GenNetMed Univ Ioannina, Ctr Biosyst & Genom Network Med CBS, GR-45110 Ioannina, Greece

[2] Ioannina Univ Sch Med, Dept Surg, GR-45110 Ioannina, Greece

[3] Insubria Univ, Dept Surg Sci & Human Morphol, Varese, Italy

[4] BRFAA, Athens, Greece

来源：

FUTURE ONCOLOGY | 2014年 / 10卷 / 12期

关键词：

cancer; next-generation sequencing analyses; personalized medicine; resistance; tumor heterogeneity; PRIMARY COLORECTAL CANCERS; INTRATUMOR HETEROGENEITY; EVOLUTION; METASTASIS; SELECTION;

D O I：

10.2217/fon.14.122

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

[No abstract available]

引用

页码：1889 / 1892

页数：4

共 20 条

[1] Mutations of KRAS and BRAF in primary and matched metastatic sites of colorectal cancer [J].

Artale, Salvatore ;

Sartore-Bianchi, Andrea ;

Veronese, Silvio Marco ;

Gambi, Valentina ;

Sarnataro, Carolina Silvia ;

Gambacorta, Marcello ;

Lauricella, Calogero ;

Siena, Salvatore .

JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (25) :4217-4219

[2] Intratumor Heterogeneity and Precision of Microarray-Based Predictors of Breast Cancer Biology and Clinical Outcome [J].

Barry, William T. ;

Kernagis, Dawn N. ;

Dressman, Holly K. ;

Griffis, Ryan J. ;

Hunter, J'Vonne D. ;

Olson, John A. ;

Marks, Jeff R. ;

Ginsburg, Geoffrey S. ;

Marcom, Paul K. ;

Nevins, Joseph R. ;

Geradts, Joseph ;

Datto, Michael B. .

JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (13) :2198-2206

[3] Tumour heterogeneity in the clinic [J].

Bedard, Philippe L. ;

Hansen, Aaron R. ;

Ratain, Mark J. ;

Siu, Lillian L. .

NATURE, 2013, 501 (7467) :355-364

[4] Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies [J].

Bettegowda, Chetan ;

Sausen, Mark ;

Leary, Rebecca J. ;

Kinde, Isaac ;

Wang, Yuxuan ;

Agrawal, Nishant ;

Bartlett, Bjarne R. ;

Wang, Hao ;

Luber, Brandon ;

Alani, Rhoda M. ;

Antonarakis, Emmanuel S. ;

Azad, Nilofer S. ;

Bardelli, Alberto ;

Brem, Henry ;

Cameron, John L. ;

Lee, Clarence C. ;

Fecher, Leslie A. ;

Gallia, Gary L. ;

Gibbs, Peter ;

Le, Dung ;

Giuntoli, Robert L. ;

Goggins, Michael ;

Hogarty, Michael D. ;

Holdhoff, Matthias ;

Hong, Seung-Mo ;

Jiao, Yuchen ;

Juhl, Hartmut H. ;

Kim, Jenny J. ;

Siravegna, Giulia ;

Laheru, Daniel A. ;

Lauricella, Calogero ;

Lim, Michael ;

Lipson, Evan J. ;

Marie, Suely Kazue Nagahashi ;

Netto, George J. ;

Oliner, Kelly S. ;

Olivi, Alessandro ;

Olsson, Louise ;

Riggins, Gregory J. ;

Sartore-Bianchi, Andrea ;

Schmidt, Kerstin ;

Shih, Ie-Ming ;

Oba-Shinjo, Sueli Mieko ;

Siena, Salvatore ;

Theodorescu, Dan ;

Tie, Jeanne ;

Harkins, Timothy T. ;

Veronese, Silvio ;

Wang, Tian-Li ;

Weingart, Jon D. .

SCIENCE TRANSLATIONAL MEDICINE, 2014, 6 (224)

[5] The patterns and dynamics of genomic instability in metastatic pancreatic cancer [J].

Campbell, Peter J. ;

Yachida, Shinichi ;

Mudie, Laura J. ;

Stephens, Philip J. ;

Pleasance, Erin D. ;

Stebbings, Lucy A. ;

Morsberger, Laura A. ;

Latimer, Calli ;

McLaren, Stuart ;

Lin, Meng-Lay ;

McBride, David J. ;

Varela, Ignacio ;

Nik-Zainal, Serena A. ;

Leroy, Catherine ;

Jia, Mingming ;

Menzies, Andrew ;

Butler, Adam P. ;

Teague, Jon W. ;

Griffin, Constance A. ;

Burton, John ;

Swerdlow, Harold ;

Quail, Michael A. ;

Stratton, Michael R. ;

Iacobuzio-Donahue, Christine ;

Futreal, P. Andrew .

NATURE, 2010, 467 (7319) :1109-1113

[6] Genome remodelling in a basal-like breast cancer metastasis and xenograft [J].

Ding, Li ;

Ellis, Matthew J. ;

Li, Shunqiang ;

Larson, David E. ;

Chen, Ken ;

Wallis, Johnw. ;

Harris, Christopher C. ;

McLellan, Michael D. ;

Fulton, Robert S. ;

Fulton, Lucinda L. ;

Abbott, Rachel M. ;

Hoog, Jeremy ;

Dooling, David J. ;

Koboldt, Daniel C. ;

Schmidt, Heather ;

Kalicki, Joelle ;

Zhang, Qunyuan ;

Chen, Lei ;

Lin, Ling ;

Wendl, Michael C. ;

McMichael, Joshua F. ;

Magrini, Vincent J. ;

Cook, Lisa ;

McGrath, Sean D. ;

Vickery, Tammi L. ;

Appelbaum, Elizabeth ;

DeSchryver, Katherine ;

Davies, Sherri ;

Guintoli, Therese ;

Lin, Li ;

Crowder, Robert ;

Tao, Yu ;

Snider, Jacqueline E. ;

Smith, Scott M. ;

Dukes, Adam F. ;

Sanderson, Gabriel E. ;

Pohl, Craig S. ;

Delehaunty, Kim D. ;

Fronick, Catrina C. ;

Pape, Kimberley A. ;

Reed, Jerry S. ;

Robinson, Jody S. ;

Hodges, Jennifer S. ;

Schierding, William ;

Dees, Nathan D. ;

Shen, Dong ;

Locke, Devin P. ;

Wiechert, Madeline E. ;

Eldred, James M. ;

Peck, Josh B. .

NATURE, 2010, 464 (7291) :999-1005

[7] Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing [J].

Gerlinger, Marco ;

Rowan, Andrew J. ;

Horswell, Stuart ;

Larkin, James ;

Endesfelder, David ;

Gronroos, Eva ;

Martinez, Pierre ;

Matthews, Nicholas ;

Stewart, Aengus ;

Tarpey, Patrick ;

Varela, Ignacio ;

Phillimore, Benjamin ;

Begum, Sharmin ;

McDonald, Neil Q. ;

Butler, Adam ;

Jones, David ;

Raine, Keiran ;

Latimer, Calli ;

Santos, Claudio R. ;

Nohadani, Mahrokh ;

Eklund, Aron C. ;

Spencer-Dene, Bradley ;

Clark, Graham ;

Pickering, Lisa ;

Stamp, Gordon ;

Gore, Martin ;

Szallasi, Zoltan ;

Downward, Julian ;

Futreal, P. Andrew ;

Swanton, Charles .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (10) :883-892

[8] Clonal evolution in cancer [J].

Greaves, Mel ;

Maley, Carlo C. .

NATURE, 2012, 481 (7381) :306-313

[9] The $1,000 genome [J].

Hayden, Erika Check .

NATURE, 2014, 507 (7492) :294-295

[10] Selection and adaptation during metastatic cancer progression [J].

Klein, Christoph A. .

NATURE, 2013, 501 (7467) :365-372

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