Selenium, copper, zinc, iron levels and mortality in patients with sepsis and systemic inflammatory response syndrome in Western Black Sea Region, Turkey

Objective: To evaluate the changing levels of selenium, copper, zinc and iron in patients with sepsis and systemic inflammatory response syndrome and their influence on mortality. Methods: The prospective study was conducted at a tertiary care university hospital in Zonguldak city in the western Black Sea region of Turkey from January 2012 to December 2013, and comprised patients with sepsis and systemic inflammatory response syndrome. Blood samples were taken on 1st, 3rd, 5th and 7th days to measure serum selenium, copper, zinc and iron levels. Patients' demographic data, presence of additional diseases and mortality were recorded. Results: Of the 57 patients, 28(49.1%) were female and 29(50.9%) weremale, with an overallmean age of 60.3 +/- 19.4 years, mean height of 166.1 +/- 11.4cm, mean weight of 76.5 +/- 17.5kg. Copper and zinc levels were in the normal range, while selenium and iron levels were lower than the limit values at all measuring periods. There was no significant difference between first and other days in accordance with element levels (p>0.05). Baseline copper levels in patients with malignancy were lower than patients without malignancy (p<0.05). In hypertensive patients, baseline copper levels were higher and 7th day levels were lower than non-hypertensive (p<0.05). Baseline selenium levels of those who died were lower than the other patients (p<0.05). Selenium and iron levels were decreased in patients with sepsis-systemic inflammatory response syndrome and copper levels were lower in patients with malignancy, hypertension and chronic obstructive pulmonary disease (p<0.05). There was no change in zinc levels of the patients. Conclusion: Reduced basal selenium levels of patients with sepsis and systemic inflammatory response syndrome were associated with mortality.