The neurobiological reward system and binge eating: A critical systematic review of neuroimaging studies

被引:47
作者
Leenaerts, Nicolas [1 ]
Jongen, Danielle [2 ]
Ceccarini, Jenny [3 ]
Van Oudenhove, Lukas [2 ,4 ]
Vrieze, Elske [1 ]
机构
[1] Katholieke Univ Leuven, Biomed Sci Grp, Mind Body Res, B-3000 Leuven, Belgium
[2] Katholieke Univ Leuven, Dept Chron Dis & Metab CHROMETA, Lab Brain Gut Axis Studies LaBGAS, Translat Res Ctr Gastrointestinal Disorders TARGI, Leuven, Belgium
[3] Katholieke Univ Leuven, Dept Imaging & Pathol, Nucl Med & Mol Imaging, Leuven, Belgium
[4] Dartmouth Coll, Dept Psychol & Brain Sci, Cognit & Affect Neurosci Lab, Hanover, NH 03755 USA
关键词
anorexia nervosa binge-eating; purging type; binge eating; binge-eating disorder; bulimia nervosa; MRI; neuroimaging; PET; RDoC; reward processing; INCENTIVE-SENSITIZATION THEORY; BULIMIA-NERVOSA; ANOREXIA-NERVOSA; FUNCTIONAL CONNECTIVITY; ORBITOFRONTAL CORTEX; STRIATAL DOPAMINE; NEURAL BASIS; FOOD-INTAKE; BRAIN; DISORDERS;
D O I
10.1002/eat.23776
中图分类号
B849 [应用心理学];
学科分类号
040203 ;
摘要
Objective Changes in reward processing are hypothesized to play a role in the onset and maintenance of binge eating (BE). However, despite an increasing number of studies investigating the neurobiological reward system in individuals who binge eat, no comprehensive systematic review exists on this topic. Therefore, this review has the following objectives: (1) identify structural and functional changes in the brain reward system, either during rest or while performing a task; and (2) formulate directions for future research. Methods A search was conducted of articles published until March 31, 2022. Neuroimaging studies were eligible if they wanted to study the reward system and included a group of individuals who binge eat together with a comparator group. Their results were summarized in a narrative synthesis. Results A total of 58 articles were included. At rest, individuals who binge eat displayed a lower striatal dopamine release, a change in the volume of the striatum, frontal cortex, and insula, as well as a lower frontostriatal connectivity. While performing a task, there was a higher activity of the brain reward system when anticipating or receiving food, more model-free reinforcement learning, and more habitual behavior. Most studies only included one patient group, used general reward-related measures, and did not evaluate the impact of comorbidities, illness duration, race, or sex. Discussion Confirming previous hypotheses, this review finds structural and functional changes in the neurobiological reward system in BE. Future studies should compare disorders, use measures that are specific to BE, and investigate the impact of confounding factors. Public Significance Statement This systematic review finds that individuals who binge eat display structural and functional changes in the brain reward system. These changes could be related to a higher sensitivity to food, relying more on previous experiences when making decisions, and more habitual behavior. Future studies should use a task that is specific to binge eating, look across different patient groups, and investigate the impact of comorbidities, illness duration, race, and sex.
引用
收藏
页码:1421 / 1458
页数:38
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