Tear film and ocular surface tests in animal models of dry eye: uses and limitations

被引：79
作者：
Barabino, S
Chen, W
Dana, MR
机构：
[1] Harvard Univ, Sch Med, Dept Ophthalmol, Stephen Eye Res Inst,Lab Immunol, Boston, MA 02114 USA
[2] Harvard Univ, Massachusetts Eye & Ear Infirm, Sch Med, Cornea Serv,Dept Ophthalmol, Boston, MA 02114 USA
[3] Univ Genoa, Dept Neurosci Ophthalmol & Genet, Genoa, Italy
来源：
EXPERIMENTAL EYE RESEARCH | 2004年 / 79卷 / 05期
关键词：
tear film; ocular surface; dry eye; animal models; apoptosis;
D O I：
10.1016/j.exer.2004.07.002
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Many ocular surface tests have been developed for the clinical diagnosis of keratoconjunctivitis sicca, and several have been used to 'validate' animal models of Sjogren's and non-Sjogren's dry eye. However, many of these tests themselves have not been systematically studied or standardized, and yet their use in animal models of dry eye is common. This review provides a rational approach and systematic review of the tear film and ocular surface tests described in the literature that may be applicable to the current animal models of dry eye, with particular emphasis on their limitations, along with some suggestions regarding their standardization and applications in eye research. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：613 / 621
页数：9
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