Protein phosphatase 2A as a therapeutic target in inflammation and neurodegeneration

被引：70

作者：

Clark, Andrew R. ^{[1
]}

Ohlmeyer, Michael ^{[2
]}

机构：

[1] Univ Birmingham, Coll Med & Dent Sci, Inst Inflammat & Ageing, Birmingham B15 2TT, W Midlands, England

[2] Atux Iskay LLC, Plainsboro, NJ USA

来源：

PHARMACOLOGY & THERAPEUTICS | 2019年 / 201卷

基金：

英国医学研究理事会;

关键词：

Protein phosphatase 2A; Inflammation; Cancer; Neurodegeneration; Alzheimer's disease; Multiple sclerosis; NF-KAPPA-B; CHRONIC LYMPHOCYTIC-LEUKEMIA; DENDRITIC CELL-MIGRATION; CENTRAL-NERVOUS-SYSTEM; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; SPHINGOSINE 1-PHOSPHATE RECEPTOR-1; IMPROVES COGNITIVE PERFORMANCE; FIBROBLAST-LIKE SYNOVIOCYTES; CHRONIC MYELOGENOUS LEUKEMIA; FACTOR-ALPHA PRODUCTION;

D O I：

10.1016/j.pharmthera.2019.05.016

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Protein phosphatase 2A (PP2A) is a highly complex heterotrimeric enzyme that catalyzes the selective removal of phosphate groups from protein serine and threonine residues. Emerging evidence suggests that it functions as a tumor suppressor by constraining phosphorylation-dependent signalling pathways that regulate cellular transformation and metastasis. Therefore, PP2A-activating drugs (PADs) are being actively sought and investigated as potential novel anti-cancer treatments. Here we explore the concept that PP2A also constrains inflammatory responses through its inhibitory effects on various signalling pathways, suggesting that PADs may be effective in the treatment of inflammation-mediated pathologies. (C) 2019 Published by Elsevier Inc.

引用

页码：181 / 201

页数：21

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