Monitoring progress toward measles elimination by genetic diversity analysis of measles viruses in China 2009-2010

被引：22

作者：

Zhang, Y. ^{[1
]}

Wang, H. ^{[1
]}

Xu, S. ^{[1
]}

Mao, N. ^{[1
]}

Zhu, Z. ^{[1
]}

Shi, J. ^{[1
]}

Huang, G. ^{[1
]}

Liu, C. ^{[2
,3
]}

Bo, F. ^{[4
]}

Feng, D. ^{[5
]}

Lu, P. ^{[6
]}

Liu, Y. ^{[7
,20
]}

Wang, Y. ^{[8
]}

Lei, Y. ^{[9
,26
]}

Chen, M. ^{[10
]}

Chen, H. ^{[11
]}

Wang, C. ^{[12
]}

Fu, H. ^{[13
]}

Li, C. ^{[14
]}

He, J. ^{[15
]}

Gao, H. ^{[16
]}

Gu, S. ^{[17
]}

Wang, S. ^{[18
]}

Ling, H. ^{[19
]}

Liu, Y. ^{[7
,20
]}

Ding, Z. ^{[21
]}

Ba, Z. ^{[22
]}

Feng, Y. ^{[23
]}

Zheng, H. ^{[24
]}

Tang, X. ^{[25
]}

Lei, Y. ^{[9
,26
]}

Xiong, Y. ^{[27
]}

Bellini, W. J. ^{[28
]}

Rota, P. A. ^{[28
]}

Jee, Y. ^{[29
]}

Xu, W. ^{[1
]}

机构：

[1] China Ctr Dis Control & Prevent, WHO WPRO Reg Reference Measles Lab, Natl Inst Viral Dis Control & Prevent, Key Lab Med Virol,Minist Hlth, Beijing 102206, Peoples R China

[2] Chinese Acad Med Sci, Inst Pathogen Biol, Beijing 100730, Peoples R China

[3] Peking Union Med Coll, Beijing 100021, Peoples R China

[4] Heilongjiang Prov Ctr Dis Control & Prevent, Haerbin, Heilongjiang, Peoples R China

[5] Henan Prov Ctr Dis Control & Prevent, Zhengzhou, Henan, Peoples R China

[6] Jiangsu Prov Ctr Dis Control & Prevent, Nanjing, Jiangsu, Peoples R China

[7] Hebei Prov Ctr Dis Control & Prevent, Baoding, Hebei, Peoples R China

[8] Liaoning Prov Ctr Dis Control & Prevent, Shenyang, Liaoning, Peoples R China

[9] Tianjin Ctr Dis Control & Prevent, Tianjin, Peoples R China

[10] Beijing Ctr Dis Control & Prevent, Beijing, Peoples R China

[11] Ningxia Prov Ctr Dis Control & Prevent, Ningxia, Peoples R China

[12] Shandong Prov Ctr Dis Control & Prevent, Jinan, Shandong, Peoples R China

[13] Gansu Prov Ctr Dis Control & Prevent, Lanzhou, Gansu, Peoples R China

[14] Shanghai Ctr Dis Control & Prevent, Shanghai, Peoples R China

[15] Sichuan Prov Ctr Dis Control & Prevent, Chengdu, Sichuan, Peoples R China

[16] Shanxi Prov Ctr Dis Control & Prevent, Taiyuan, Shanxi, Peoples R China

[17] Innermongolia Prov Ctr Dis Control & Prevent, Hohhot, Innermongolia, Peoples R China

[18] Jilin Prov Ctr Dis Control & Prevent, Changchun, Jilin, Peoples R China

[19] Chongqing Ctr Dis Control & Prevent, Chongqing, Peoples R China

[20] Hunan Prov Ctr Dis Control & Prevent, Changsha, Hunan, Peoples R China

[21] Yunnan Prov Ctr Dis Control & Prevent, Kunming, Yunnan, Peoples R China

[22] Qinghai Prov Ctr Dis Control & Prevent, Xining, Peoples R China

[23] Zhejiang Prov Ctr Dis Control & Prevent, Hangzhou, Zhejiang, Peoples R China

[24] Guangdong Prov Ctr Dis Control & Prevent, Guangzhou, Guangdong, Peoples R China

[25] Guizhou Prov Ctr Dis Control & Prevent, Guiyang, Guizhou, Peoples R China

[26] Hubei Prov Ctr Dis Control & Prevent, Wuhan, Hubei, Peoples R China

[27] Jiangxi Prov Ctr Dis Control & Prevent, Nanchang, Jiangxi, Peoples R China

[28] Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA USA

[29] WHO, Western Pacific Reg Off, Expanded Programme Immunizat, Manila, Philippines

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2014年 / 20卷 / 09期

基金：

中国国家自然科学基金;

关键词：

GLOBAL DISTRIBUTION; UNITED-STATES; EPIDEMIOLOGY; GENOTYPES; OUTBREAK;

D O I：

10.1111/1469-0691.12530

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

With the achievement of high coverage for routine immunization and supplementary immunization activities (SIAs), measles incidence in mainland China reached its lowest level in 2010. The proportion of measles cases in the vaccination-targeted population decreased during 2007-2010 after the SIAs. More than 60% of measles cases were in adults or infants, especially in the coastal and eastern provinces during 2009 and 2010. A total 567 isolates of measles virus were obtained from clinical specimens from 27 of 31 provinces in mainland China during 2009 and 2010. Except for two vaccine-associated cases, one genotypeD4 strain, two genotypeD9 strains, and four genotypeD11 strains, the other 558 strains were genotypeH1 clusterH1a. GenotypeH1 has been the only endemic genotype detected in China since surveillance began in 1993. Only genotypeH1 was found in mainland China during 1993-2008, except for one detection of genotypeH2. More recently, multiple genotypes of imported measles were detected even with the background of endemic genetotypeH1 viruses. Analysis of the 450-nucleotide sequencing window of the measles virus N gene showed that the overall genetic diversity of the recent geneotypeH1 strains decreased between 2008 and 2010. The lower genetic diversity of H1 strains suggested that enhanced vaccination may have reduced the co-circulating lineages of endemic genotypeH1 strains in mainland China.

引用

页码：O566 / O577

页数：12