A functional human IgM response to HIV-1 Env after immunization with NYVAC HIVC

被引：9
作者：
Sheppard, Neil C. [1 ]
Bates, Anna C. [1 ]
Sattentau, Quentin J. [1 ]
机构：
[1] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England
来源：
AIDS | 2007年 / 21卷 / 04期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1097/QAD.0b013e32803277f9
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Env-specific IgG and IgM were detected in 25 and 60%, respectively, of volunteers immunized with NYVAC expressing clade C gp120. The serum sample with the highest IgM titre but undetectable IgG neutralized the homologous isolate with a reciprocal IC90 titre of 7.8 in the absence of complement, and 24.4 in the presence of complement (P=0.0003). These results suggest that vaccine-induced, Env-specific IgM may have antiviral activity and should be subjected to further investigation.
引用
收藏
页码：524 / 527
页数：4
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