Human CARD9: A Critical Molecule of Fungal Immune Surveillance

被引：112

作者：

Drummond, Rebecca A. ^{[1
,3
]}

Franco, Luis M. ^{[2
]}

Lionakis, Michail S. ^{[1
]}

机构：

[1] NIAID, Fungal Pathogenesis Sect, LCIM, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

[2] NIAID, LISB, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

[3] Univ Birmingham, Inst Immunol & Immunotherapy, Inst Microbiol & Infect, Birmingham, W Midlands, England

来源：

FRONTIERS IN IMMUNOLOGY | 2018年 / 9卷

基金：

美国国家卫生研究院;

关键词：

CARD9; fungi; primary immunodeficiency; C-type lectin receptors; candidiasis; neutrophils; INFLAMMATORY-BOWEL-DISEASE; INNATE ANTIFUNGAL IMMUNITY; CANDIDA-ALBICANS; SUSCEPTIBILITY; INFECTIONS; DEFICIENCY; RESPONSES; COLITIS; ADAPTER; CELLS;

D O I：

10.3389/fimmu.2018.01836

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CARD9 is a signaling adaptor protein that is involved in the transduction of signals from a variety of innate pattern recognition receptors, including the C-type lectin receptors and intracellular NOD receptors and nucleic acid sensors. As a result, CARD9 has been shown in animal models to be an important regulator of immunity to bacteria, fungi, and viruses. Studies in humans with autosomal recessive CARD9 deficiency have indicated a highly specific role for this molecule in the activation of antifungal immune responses in the central nervous system, the oral mucosa, and the skin. Moreover, CARD9-dependent functions have recently been indicated to modulate the development of autoimmunity, inflammatory bowel diseases, and cancer. In this mini-review, we highlight the recent studies that have identified several novel functions of CARD9 in various disease contexts, and we summarize the contemporary understanding of the genetics and immunology of human CARD9 deficiency.

引用

页数：7

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