Cortical spreading depression and estrogen

被引：33

作者：

Eikermann-Haerter, Katharina ^{[1
]}

Kudo, Chiho ^{[1
]}

Moskowitz, Michael A. ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Ctr Neurosci, Harvard Med Sch, Harvard MIT Div Hlth & Sci Technol, Charlestown, MA 02129 USA

来源：

HEADACHE | 2007年 / 47卷

关键词：

cortical spreading depression; familial hemiplegic migraine; estrogen;

D O I：

10.1111/j.1526-4610.2007.00818.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cortical spreading depression (CSD) is an electrophysiological phenomenon characterized by a wave of excitation followed by inhibition. The aura phase that precedes migraine headache in about 20-30% of migraineurs shares overlapping characteristics with CSD. Studies of rare autosomal-dominant forms of migraine with aura provide strong evidence that the threshold for evoking CSD and aura are related to neuronal excitability. Although the relationship between CSD and migraine without aura is not completely understood, the molecular abnormalities that predispose to migraine with aura illustrate the importance of physiologic events associated with neuronal hyperexcitability, and provide a basis for understanding a more generalized view of migraine.

引用

页码：S79 / S85

页数：7

共 27 条

[1] Cortical inhibition is reduced in chronic and episodic migraine and demonstrates a spectrum of illness [J].